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Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.
Dias, Kris Simone T; de Paula, Cynthia T; Dos Santos, Thiago; Souza, Isis N O; Boni, Marina S; Guimarães, Marcos J R; da Silva, Fernanda M R; Castro, Newton G; Neves, Gilda A; Veloso, Clarice C; Coelho, Márcio M; de Melo, Ivo Souza F; Giusti, Fabiana C V; Giusti-Paiva, Alexandre; da Silva, Marcelo L; Dardenne, Laurent E; Guedes, Isabella A; Pruccoli, Letizia; Morroni, Fabiana; Tarozzi, Andrea; Viegas, Claudio.
Afiliación
  • Dias KS; PeQuiM- Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, 37130-000, Alfenas, MG, Brazil.
  • de Paula CT; PeQuiM- Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, 37130-000, Alfenas, MG, Brazil.
  • Dos Santos T; PeQuiM- Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, 37130-000, Alfenas, MG, Brazil.
  • Souza IN; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, RJ, Brazil.
  • Boni MS; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, RJ, Brazil.
  • Guimarães MJ; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, RJ, Brazil.
  • da Silva FM; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, RJ, Brazil.
  • Castro NG; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, RJ, Brazil.
  • Neves GA; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, RJ, Brazil.
  • Veloso CC; Pharmaceutical Sciences Faculty, Federal University of Amazonas (UFAM), 69067-005, Manaus, AM, Brazil.
  • Coelho MM; Department of Pharmaceutical Products, Pharmaceutical Faculty, Federal University of Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil.
  • de Melo IS; Department of Pharmaceutical Products, Pharmaceutical Faculty, Federal University of Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil.
  • Giusti FC; Department of Physiological Sciences, Federal University of Alfenas, 37130-000, Alfenas, MG, Brazil.
  • Giusti-Paiva A; Department of Physiological Sciences, Federal University of Alfenas, 37130-000, Alfenas, MG, Brazil.
  • da Silva ML; Physiotherapy Department, Federal University of Alfenas, 37130-000, Alfenas, MG, Brazil.
  • Dardenne LE; National Laboratory of Scientific Computation, 25651-075, Petrópolis, RJ, Brazil.
  • Guedes IA; National Laboratory of Scientific Computation, 25651-075, Petrópolis, RJ, Brazil.
  • Pruccoli L; Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, 47921 Rimini, Italy.
  • Morroni F; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.
  • Tarozzi A; Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, 47921 Rimini, Italy.
  • Viegas C; PeQuiM- Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, 37130-000, Alfenas, MG, Brazil. Electronic address: cvjviegas@gmail.com.
Eur J Med Chem ; 130: 440-457, 2017 Apr 21.
Article en En | MEDLINE | ID: mdl-28282613
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperidinas / Terapia Molecular Dirigida / Enfermedad de Alzheimer / Indanos Límite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Año: 2017 Tipo del documento: Article País de afiliación: Brasil
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperidinas / Terapia Molecular Dirigida / Enfermedad de Alzheimer / Indanos Límite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Año: 2017 Tipo del documento: Article País de afiliación: Brasil