Two mechanisms for the extinction of gene expression in hybrid cells.
Science
; 241(4870): 1205-7, 1988 Sep 02.
Article
en En
| MEDLINE
| ID: mdl-2842865
ABSTRACT
When two different mammalian cell types are fused to generate a stable hybrid cell line, genes that are active in only one of the parents are frequently shut off, a phenomenon called extinction. In this study two distinct, complementary mechanisms for such extinction of growth hormone gene expression were identified. In hybrids formed by fusing fibroblasts to pituitary cells, pituitary-specific proteins that bind to the growth hormone promoter were absent. In addition, a negative regulatory element located near the rat growth hormone promoter was specifically activated.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hormona del Crecimiento
/
Regulación de la Expresión Génica
/
Células Híbridas
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1988
Tipo del documento:
Article