An attenuated Mycobacterium tuberculosis clinical strain with a defect in ESX-1 secretion induces minimal host immune responses and pathology.

Clemmensen, Helena Strand; Knudsen, Niels Peter Hell; Rasmussen, Erik Michael; Winkler, Jessica; Rosenkrands, Ida; Ahmad, Ahmad; Lillebaek, Troels; Sherman, David R; Andersen, Peter Lawætz; Aagaard, Claus

Clemmensen, Helena Strand; Knudsen, Niels Peter Hell; Rasmussen, Erik Michael; Winkler, Jessica; Rosenkrands, Ida; Ahmad, Ahmad; Lillebaek, Troels; Sherman, David R; Andersen, Peter Lawætz; Aagaard, Claus.

Afiliación

Clemmensen HS; Department of Infectious Disease Immunology, Statens Serum Institut, DK-2300, Copenhagen, Denmark.
Knudsen NPH; Department of Infectious Disease Immunology, Statens Serum Institut, DK-2300, Copenhagen, Denmark.
Rasmussen EM; International Reference Laboratory of Mycobacteriology, Statens Serum Institut, DK-2300, Copenhagen, Denmark.
Winkler J; Center for Infectious Disease Research, Seattle, Washington, 98109, USA.
Rosenkrands I; Department of Infectious Disease Immunology, Statens Serum Institut, DK-2300, Copenhagen, Denmark.
Ahmad A; Department of Infectious Disease Immunology, Statens Serum Institut, DK-2300, Copenhagen, Denmark.
Lillebaek T; International Reference Laboratory of Mycobacteriology, Statens Serum Institut, DK-2300, Copenhagen, Denmark.
Sherman DR; Center for Infectious Disease Research, Seattle, Washington, 98109, USA.
Andersen PL; Department of Infectious Disease Immunology, Statens Serum Institut, DK-2300, Copenhagen, Denmark.
Aagaard C; Department of Infectious Disease Immunology, Statens Serum Institut, DK-2300, Copenhagen, Denmark.

Sci Rep ; 7: 46666, 2017 04 24.

Article en En | MEDLINE | ID: mdl-28436493

Asunto(s)

Antígenos Bacterianos/inmunología; Proteínas Bacterianas/inmunología; Mycobacterium tuberculosis/inmunología; Tuberculosis/inmunología; Factores de Virulencia/inmunología; Animales; Antígenos Bacterianos/genética; Proteínas Bacterianas/genética; Citocinas/inmunología; Citocinas/metabolismo; Femenino; Interacciones Huésped-Patógeno; Humanos; Ratones; Mutación; Mycobacterium tuberculosis/clasificación; Mycobacterium tuberculosis/genética; Mycobacterium tuberculosis/patogenicidad; Filogenia; Especificidad de la Especie; Linfocitos T/inmunología; Linfocitos T/metabolismo; Linfocitos T/microbiología; Células THP-1; Tuberculosis/microbiología; Vacunación/métodos; Virulencia/genética; Factores de Virulencia/genética

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Tuberculosis / Factores de Virulencia / Mycobacterium tuberculosis / Antígenos Bacterianos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Dinamarca

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