Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding.

Allan, Christopher M; Jung, Cris J; Larsson, Mikael; Heizer, Patrick J; Tu, Yiping; Sandoval, Norma P; Dang, Tiffany Ly P; Jung, Rachel S; Beigneux, Anne P; de Jong, Pieter J; Fong, Loren G; Young, Stephen G

Allan, Christopher M; Jung, Cris J; Larsson, Mikael; Heizer, Patrick J; Tu, Yiping; Sandoval, Norma P; Dang, Tiffany Ly P; Jung, Rachel S; Beigneux, Anne P; de Jong, Pieter J; Fong, Loren G; Young, Stephen G.

Afiliación

Allan CM; Departments of Medicine University of California Los Angeles, Los Angeles, CA 90095.
Jung CJ; Children's Hospital Oakland Research Institute, Oakland, CA 94609.
Larsson M; Departments of Medicine University of California Los Angeles, Los Angeles, CA 90095.
Heizer PJ; Departments of Medicine University of California Los Angeles, Los Angeles, CA 90095.
Tu Y; Departments of Medicine University of California Los Angeles, Los Angeles, CA 90095.
Sandoval NP; Departments of Medicine University of California Los Angeles, Los Angeles, CA 90095.
Dang TLP; Departments of Medicine University of California Los Angeles, Los Angeles, CA 90095.
Jung RS; Departments of Medicine University of California Los Angeles, Los Angeles, CA 90095.
Beigneux AP; Departments of Medicine University of California Los Angeles, Los Angeles, CA 90095. Electronic address: abeigneux@mednet.ucla.edu.
de Jong PJ; Children's Hospital Oakland Research Institute, Oakland, CA 94609.
Fong LG; Departments of Medicine University of California Los Angeles, Los Angeles, CA 90095. Electronic address: lfong@mednet.ucla.edu.
Young SG; Departments of Medicine University of California Los Angeles, Los Angeles, CA 90095; Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095. Electronic address: sgyoung@mednet.ucla.edu.

J Lipid Res ; 58(7): 1453-1461, 2017 07.

Article en En | MEDLINE | ID: mdl-28476858

Asunto(s)

Secuencia Conservada; Cisteína; Lipoproteína Lipasa/metabolismo; Mutación; Receptores de Lipoproteína/química; Receptores de Lipoproteína/metabolismo; Animales; Células CHO; Cricetinae; Cricetulus; Femenino; Humanos; Lipoproteína Lipasa/genética; Ratones; Unión Proteica/genética; ARN Mensajero/genética; ARN Mensajero/metabolismo; Receptores de Lipoproteína/genética; Triglicéridos/sangre

Palabras clave

chylomicrons; endothelial cells; glycosylphosphatidylinositol-anchored HDL binding protein 1; lipids/chemistry; lipolysis and fatty acid metabolism; lipoprotein lipase; triglycerides

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Secuencia Conservada / Receptores de Lipoproteína / Cisteína / Lipoproteína Lipasa / Mutación Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: J Lipid Res Año: 2017 Tipo del documento: Article

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