Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata.
Planta Med
; 83(17): 1368-1373, 2017 Nov.
Article
en En
| MEDLINE
| ID: mdl-28662527
ABSTRACT
Three new compounds (1â-â3), including a sesterterpenoid, aspterpenacid C (1), with an unusual 5/3/7/6/5 pentacyclic skeleton, together with seven known ones (4â-â10), were isolated from the ethanol extract of the traditional Chinese medicinal plant Swertia bimaculata. Their structures were elucidated on the basis of the methods of spectroscopic NMR, MS, and computational chemistry. The structure of 1 was further confirmed by single-crystal X-ray diffraction analysis. Compounds 1â-â10 were tested for activities on the inhibition of nitric oxide production and HIV-1 replication in vitro. Compound 1 exhibited moderate activity in inhibiting nitric oxide production (IC50 = 16.1 µM) and HIV-1 replication (EC50 = 1.35 µM).
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Medicamentos Herbarios Chinos
/
VIH-1
/
Fármacos Anti-VIH
/
Swertia
/
Antiinflamatorios
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
Planta Med
Año:
2017
Tipo del documento:
Article
País de afiliación:
China