A novel in vitro model of villitis of unknown etiology demonstrates altered placental hormone and cytokine profile.
Am J Reprod Immunol
; 78(5)2017 Nov.
Article
en En
| MEDLINE
| ID: mdl-28681959
ABSTRACT
PROBLEM:
Placental dysfunction is present over 50% of cases of stillbirth and fetal growth restriction (FGR). Villitis of unknown etiology (VUE), an inflammatory condition of the placenta characterized by maternal T cell infiltrates in the villous stroma and dysregulation of inflammatory cytokines, is more frequent in FGR and stillbirth. METHOD OF STUDY A novel in vitro model of placental inflammation was developed to test the hypothesis that inflammatory cells seen in VUE and/or cytokines impair placental function.RESULTS:
Coculture of placental explants with maternal leukocytes resulted in increased leukocytes in villous tissue and elevated concentrations of IL-1ß, IL-1Ra, IL-6, IL-10, and IFN-γ (P≤.05). Human chorionic gonadotrophin secretion was reduced following coculture with leukocytes (P≤.01) and cytokines (P≤.05).CONCLUSION:
These observations support the hypothesis that altered placental inflammation has deleterious effects on placental function. This model could be used to further understanding about the pathophysiology of VUE and to test potential therapies.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Placenta
/
Linfocitos T
/
Corioamnionitis
/
Vellosidades Coriónicas
/
Retardo del Crecimiento Fetal
/
Gonadotropina Coriónica
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Female
/
Humans
/
Middle aged
/
Pregnancy
Idioma:
En
Revista:
Am J Reprod Immunol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Reino Unido