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Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors.
Schenkel, Laurie B; DiMauro, Erin F; Nguyen, Hanh N; Chakka, Nagasree; Du, Bingfan; Foti, Robert S; Guzman-Perez, Angel; Jarosh, Michael; La, Daniel S; Ligutti, Joseph; Milgram, Benjamin C; Moyer, Bryan D; Peterson, Emily A; Roberts, John; Yu, Violeta L; Weiss, Matthew M.
Afiliación
  • Schenkel LB; Department of Therapeutic Discovery, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, United States. Electronic address: mmweiss@amgen.com.
  • DiMauro EF; Department of Therapeutic Discovery, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, United States.
  • Nguyen HN; Department of Therapeutic Discovery, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, United States.
  • Chakka N; Department of Therapeutic Discovery, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, United States.
  • Du B; Department of Therapeutic Discovery, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, United States.
  • Foti RS; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, United States.
  • Guzman-Perez A; Department of Therapeutic Discovery, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, United States.
  • Jarosh M; Department of Neuroscience, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, United States.
  • La DS; Department of Therapeutic Discovery, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, United States.
  • Ligutti J; Department of Neuroscience, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States.
  • Milgram BC; Department of Therapeutic Discovery, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, United States.
  • Moyer BD; Department of Neuroscience, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States.
  • Peterson EA; Department of Therapeutic Discovery, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, United States.
  • Roberts J; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, United States.
  • Yu VL; Department of Neuroscience, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, United States.
  • Weiss MM; Department of Therapeutic Discovery, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, United States.
Bioorg Med Chem Lett ; 27(16): 3817-3824, 2017 08 15.
Article en En | MEDLINE | ID: mdl-28684121
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Descubrimiento de Drogas / Canal de Sodio Activado por Voltaje NAV1.7 / Amidas Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Descubrimiento de Drogas / Canal de Sodio Activado por Voltaje NAV1.7 / Amidas Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article