Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions.
Part Fibre Toxicol
; 14(1): 25, 2017 07 17.
Article
en En
| MEDLINE
| ID: mdl-28716104
ABSTRACT
BACKGROUND:
As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about the long term effects of these materials. This study was designed to evaluate whether gold (10 nm), silver (50 nm), or silica (10 nm) nanoparticles administered intravenously to mice for up to 8 weeks at doses known to be sub-toxic (non-toxic at single acute or repeat dosing levels) and clinically relevant could produce significant bioaccumulation in liver and spleen macrophages.RESULTS:
Repeated dosing with gold, silver, and silica nanoparticles did not saturate bioaccumulation in liver or spleen macrophages. While no toxicity was observed with gold and silver nanoparticles throughout the 8 week experiment, some effects including histopathological and serum chemistry changes were observed with silica nanoparticles starting at week 3. No major changes in the splenocyte population were observed during the study for any of the nanoparticles tested.CONCLUSIONS:
The clinical impact of these changes is unclear but suggests that the mononuclear phagocytic system is able to handle repeated doses of nanoparticles.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Plata
/
Bazo
/
Dióxido de Silicio
/
Nanopartículas
/
Oro
/
Hígado
/
Macrófagos
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Part Fibre Toxicol
Asunto de la revista:
TOXICOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos