New Coumarin Derivatives as Anti-Breast and Anti-Cervical Cancer Agents Targeting VEGFR-2 and p38&#945; MAPK.

Batran, Rasha Z; Dawood, Dina H; El-Seginy, Samia A; Ali, Mamdouh M; Maher, Timothy J; Gugnani, Kuljeet S; Rondon-Ortiz, Alejandro N

New Coumarin Derivatives as Anti-Breast and Anti-Cervical Cancer Agents Targeting VEGFR-2 and p38α MAPK.

Batran, Rasha Z; Dawood, Dina H; El-Seginy, Samia A; Ali, Mamdouh M; Maher, Timothy J; Gugnani, Kuljeet S; Rondon-Ortiz, Alejandro N.

Afiliación

Batran RZ; Department of Chemistry of Natural Compounds, Division of Pharmaceutical Industries Research, National Research Center, Dokki, Giza, Egypt.
Dawood DH; Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical Industries Research, National Research Center, Dokki, Giza, Egypt.
El-Seginy SA; Department of Green Chemistry, Division of Chemical Industries Research, National Research Center, Dokki, Giza, Egypt.
Ali MM; Department of Biochemistry, Division of Genetic Engineering and Biotechnology Research, National Research Center, Dokki, Giza, Egypt.
Maher TJ; Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA.
Gugnani KS; Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA.
Rondon-Ortiz AN; Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA.

Arch Pharm (Weinheim) ; 350(9)2017 Sep.

Article en En | MEDLINE | ID: mdl-28787092

Asunto(s)

Antineoplásicos/síntesis química; Antineoplásicos/farmacología; Neoplasias de la Mama/tratamiento farmacológico; Cumarinas/síntesis química; Cumarinas/farmacología; Neoplasias del Cuello Uterino/tratamiento farmacológico; Receptor 2 de Factores de Crecimiento Endotelial Vascular/efectos de los fármacos; Proteínas Quinasas p38 Activadas por Mitógenos/efectos de los fármacos; Femenino; Células HeLa; Humanos; Células MCF-7; Modelos Moleculares

Palabras clave

Breast cancer; Cervical cancer; Fluorinated coumarins; Molecular modeling; QSAR; VEGFR-2; p38α MAPK

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias del Cuello Uterino / Cumarinas / Receptor 2 de Factores de Crecimiento Endotelial Vascular / Proteínas Quinasas p38 Activadas por Mitógenos / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Arch Pharm (Weinheim) Año: 2017 Tipo del documento: Article País de afiliación: Egipto

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