NK cells of HIV-1-infected patients with poor CD4<sup>+</sup> T-cell reconstitution despite suppressive HAART show reduced IFN-Î³ production and high frequency of autoreactive CD56<sup>bright</sup> cells.

Giuliani, Erica; Vassena, Lia; Di Cesare, Silvia; Malagnino, Vincenzo; Desimio, Maria Giovanna; Andreoni, Massimo; Barnaba, Vincenzo; Doria, Margherita

NK cells of HIV-1-infected patients with poor CD4⁺ T-cell reconstitution despite suppressive HAART show reduced IFN-Î³ production and high frequency of autoreactive CD56^bright cells.

Giuliani, Erica; Vassena, Lia; Di Cesare, Silvia; Malagnino, Vincenzo; Desimio, Maria Giovanna; Andreoni, Massimo; Barnaba, Vincenzo; Doria, Margherita.

Afiliación

Giuliani E; Laboratory of Immunoinfectivology, Bambino Gesù Children's Hospital, IRCCS, Piazza S. Onofrio 4, 00165, Rome, Italy.
Vassena L; Laboratory of Immunoinfectivology, Bambino Gesù Children's Hospital, IRCCS, Piazza S. Onofrio 4, 00165, Rome, Italy.
Di Cesare S; Laboratory of Immunoinfectivology, Bambino Gesù Children's Hospital, IRCCS, Piazza S. Onofrio 4, 00165, Rome, Italy.
Malagnino V; Department of Medicine of Systems, Tor Vergata University, Via Montpellier 1, 00133, Rome, Italy.
Desimio MG; Laboratory of Immunoinfectivology, Bambino Gesù Children's Hospital, IRCCS, Piazza S. Onofrio 4, 00165, Rome, Italy.
Andreoni M; Department of Medicine of Systems, Tor Vergata University, Via Montpellier 1, 00133, Rome, Italy.
Barnaba V; Dipartimento di Medicina Interna e Specialità Mediche - Sapienza Università di Roma; Istituto Pasteur - Fondazione Cenci Bolognetti, Viale del Policlinico 155, 00161, Rome, Italy.
Doria M; Laboratory of Immunoinfectivology, Bambino Gesù Children's Hospital, IRCCS, Piazza S. Onofrio 4, 00165, Rome, Italy. Electronic address: doria@uniroma2.it.

Immunol Lett ; 190: 185-193, 2017 10.

Article en En | MEDLINE | ID: mdl-28826739

Asunto(s)

Linfocitos T CD4-Positivos/inmunología; Infecciones por VIH/inmunología; VIH-1/inmunología; Células Asesinas Naturales/inmunología; Linfocitos T Reguladores/inmunología; Adulto; Terapia Antirretroviral Altamente Activa; Autoantígenos; Autoinmunidad; Antígeno CD56/metabolismo; Resistencia a Medicamentos; Femenino; Infecciones por VIH/tratamiento farmacológico; Homeostasis; Humanos; Interferón gamma/metabolismo; Recuento de Linfocitos; Masculino; Persona de Mediana Edad

Palabras clave

CD56(bright) NK cells; Cytotoxicity; HIV-1; IFN-Î³; Immunological non-responders; Treg cells

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Linfocitos T CD4-Positivos / Infecciones por VIH / VIH-1 / Linfocitos T Reguladores Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Immunol Lett Año: 2017 Tipo del documento: Article País de afiliación: Italia

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google