Effect of Atractylodes macrocephala rhizoma on isoproterenolinduced ventricular remodeling in rats.
Mol Med Rep
; 17(2): 2607-2613, 2018 Feb.
Article
en En
| MEDLINE
| ID: mdl-29207045
ABSTRACT
Myocardial infarction (MI) is the primary cause of ventricular remodeling (VR). The aim of the present study was to determine the effect of Atractylodis macrocephalae rhizoma (AMR) on VR induced by isoproterenol (ISO) in rats. Male Sprague Dawley rats were randomly divided into the normal control, ISOinduced and AMR groups. Rats in the ISOinduced and AMR groups were subcutaneously injected with 85 mg/kg/day ISO for two consecutive days. Compared with the ISOinduced group, AMR normalized the levels of hemodynamic parameters, markedly attenuated myocardial pathological damage, decreased the level of Nterminal prohormone of brain natriuretic peptide, and inhibited cardiac hypertrophy and myocardial fibrosis. In addition, AMR inhibited oxidative stress and activation of the renninangiotensinaldosterone system (RAAS) when compared with the ISOinduced group. The results of the present study suggest that AMR may reverse VR via its antioxidative effect and inhibition of RAAS activation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Remodelación Ventricular
/
Rizoma
/
Atractylodes
/
Isoproterenol
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Mol Med Rep
Año:
2018
Tipo del documento:
Article