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A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.
Kycia, Ina; Wolford, Brooke N; Huyghe, Jeroen R; Fuchsberger, Christian; Vadlamudi, Swarooparani; Kursawe, Romy; Welch, Ryan P; Albanus, Ricardo d'Oliveira; Uyar, Asli; Khetan, Shubham; Lawlor, Nathan; Bolisetty, Mohan; Mathur, Anubhuti; Kuusisto, Johanna; Laakso, Markku; Ucar, Duygu; Mohlke, Karen L; Boehnke, Michael; Collins, Francis S; Parker, Stephen C J; Stitzel, Michael L.
Afiliación
  • Kycia I; Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Wolford BN; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
  • Huyghe JR; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
  • Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
  • Vadlamudi S; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Kursawe R; Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Welch RP; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
  • Albanus RD; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
  • Uyar A; Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Khetan S; Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Lawlor N; Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Bolisetty M; Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Mathur A; Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
  • Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
  • Ucar D; Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Institute of Systems Genomics, University of Connecticut Health Center, Farmington, CT 06032, USA.
  • Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Boehnke M; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
  • Collins FS; National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
  • Parker SCJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
  • Stitzel ML; Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Institute of Systems Genomics, University of Connecticut Health Center, Farmington, CT 06032, USA. Electronic address: michael.stitzel@jax.org.
Am J Hum Genet ; 102(4): 620-635, 2018 04 05.
Article en En | MEDLINE | ID: mdl-29625024
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Proteínas de Unión al Calcio / Proteínas Nucleares / Islotes Pancreáticos / Elementos de Facilitación Genéticos / Secuencia Conservada / Evolución Molecular / Mutación Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Animals / Humans / Middle aged Idioma: En Revista: Am J Hum Genet Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Proteínas de Unión al Calcio / Proteínas Nucleares / Islotes Pancreáticos / Elementos de Facilitación Genéticos / Secuencia Conservada / Evolución Molecular / Mutación Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Animals / Humans / Middle aged Idioma: En Revista: Am J Hum Genet Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos