Class I PI3K inhibitor ZSTK474 attenuates experimental autoimmune neuritis by decreasing the frequency of Th1/Th17 cells and reducing the production of proinflammatory cytokines.

Chen, Xiuju; Guo, Ying; Han, Ranran; Liu, Haijie; Ding, Yanan; Shi, Yanchao; Kong, Dexin; Ma, Xiaofeng

Chen, Xiuju; Guo, Ying; Han, Ranran; Liu, Haijie; Ding, Yanan; Shi, Yanchao; Kong, Dexin; Ma, Xiaofeng.

Afiliación

Chen X; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China; Department of Neurology, Tianjin Nankai Hospital, Tianjin 300100, China.
Guo Y; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China; Department of Otorhinolaryngology, Tianjin Medical University General Hospital, Tianjin 300052, China.
Han R; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
Liu H; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
Ding Y; Department of Neurology, Liaocheng People's Hospital, Liaocheng 252000, China.
Shi Y; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
Kong D; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
Ma X; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address: xfengma@tmu.edu.cn.

Cell Immunol ; 329: 41-49, 2018 07.

Article en En | MEDLINE | ID: mdl-29724464

Asunto(s)

Citocinas/efectos de los fármacos; Neuritis Autoinmune Experimental/tratamiento farmacológico; Triazinas/farmacología; Animales; Enfermedades Desmielinizantes/tratamiento farmacológico; Modelos Animales de Enfermedad; Síndrome de Guillain-Barré/tratamiento farmacológico; Masculino; Fármacos Neuroprotectores/metabolismo; Inhibidores de las Quinasa Fosfoinosítidos-3; Ratas; Ratas Endogámicas Lew; Nervio Ciático; Células TH1/efectos de los fármacos; Células Th17/efectos de los fármacos; Triazinas/metabolismo

Palabras clave

Experimental autoimmune neuritis; Inflammation; T cells; ZSTK474

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Triazinas / Citocinas / Neuritis Autoinmune Experimental Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cell Immunol Año: 2018 Tipo del documento: Article País de afiliación: China

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