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iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome.
Landucci, Elisa; Brindisi, Margherita; Bianciardi, Laura; Catania, Lorenza M; Daga, Sergio; Croci, Susanna; Frullanti, Elisa; Fallerini, Chiara; Butini, Stefania; Brogi, Simone; Furini, Simone; Melani, Riccardo; Molinaro, Angelo; Lorenzetti, Flaminia Clelia; Imperatore, Valentina; Amabile, Sonia; Mariani, Jessica; Mari, Francesca; Ariani, Francesca; Pizzorusso, Tommaso; Pinto, Anna Maria; Vaccarino, Flora M; Renieri, Alessandra; Campiani, Giuseppe; Meloni, Ilaria.
Afiliación
  • Landucci E; Medical Genetics, University of Siena, Strada delle Scotte 4, 53100, Siena, Italy.
  • Brindisi M; NatSynDrugs, Department of Biotechnology, Chemistry and Pharmacy, DoE 2018-2022 University of Siena, via Aldo Moro 2, 53100 Siena, Italy.
  • Bianciardi L; Medical Genetics, University of Siena, Strada delle Scotte 4, 53100, Siena, Italy.
  • Catania LM; Medical Genetics, University of Siena, Strada delle Scotte 4, 53100, Siena, Italy.
  • Daga S; Medical Genetics, University of Siena, Strada delle Scotte 4, 53100, Siena, Italy.
  • Croci S; Medical Genetics, University of Siena, Strada delle Scotte 4, 53100, Siena, Italy.
  • Frullanti E; Medical Genetics, University of Siena, Strada delle Scotte 4, 53100, Siena, Italy.
  • Fallerini C; Medical Genetics, University of Siena, Strada delle Scotte 4, 53100, Siena, Italy.
  • Butini S; NatSynDrugs, Department of Biotechnology, Chemistry and Pharmacy, DoE 2018-2022 University of Siena, via Aldo Moro 2, 53100 Siena, Italy.
  • Brogi S; NatSynDrugs, Department of Biotechnology, Chemistry and Pharmacy, DoE 2018-2022 University of Siena, via Aldo Moro 2, 53100 Siena, Italy.
  • Furini S; Department of Medical Biotechnologies, University of Siena, Strada delle Scotte 4, 53100 Siena, Italy.
  • Melani R; Institute of Neuroscience, National Research Council (CNR), Via Giuseppe Moruzzi, 1, 56124 Pisa, Italy.
  • Molinaro A; Institute of Neuroscience, National Research Council (CNR), Via Giuseppe Moruzzi, 1, 56124 Pisa, Italy; Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA, University of Florence, Viale Gaetano Pieraccini, 6, 50139 Florence, Italy.
  • Lorenzetti FC; Medical Genetics, University of Siena, Strada delle Scotte 4, 53100, Siena, Italy.
  • Imperatore V; Medical Genetics, University of Siena, Strada delle Scotte 4, 53100, Siena, Italy.
  • Amabile S; Medical Genetics, University of Siena, Strada delle Scotte 4, 53100, Siena, Italy.
  • Mariani J; Yale University, Child Study Center, 230 South Frontage Rd, New Haven, CT 06520, United States.
  • Mari F; Medical Genetics, University of Siena, Strada delle Scotte 4, 53100, Siena, Italy; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Viale Mario Bracci 2, 53100 Siena, Italy.
  • Ariani F; Medical Genetics, University of Siena, Strada delle Scotte 4, 53100, Siena, Italy; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Viale Mario Bracci 2, 53100 Siena, Italy.
  • Pizzorusso T; Institute of Neuroscience, National Research Council (CNR), Via Giuseppe Moruzzi, 1, 56124 Pisa, Italy; Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA, University of Florence, Viale Gaetano Pieraccini, 6, 50139 Florence, Italy; BIO@SNS lab, Scuola Normale Superiore
  • Pinto AM; Medical Genetics, University of Siena, Strada delle Scotte 4, 53100, Siena, Italy; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Viale Mario Bracci 2, 53100 Siena, Italy.
  • Vaccarino FM; Yale University, Child Study Center, 230 South Frontage Rd, New Haven, CT 06520, United States.
  • Renieri A; Medical Genetics, University of Siena, Strada delle Scotte 4, 53100, Siena, Italy; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Viale Mario Bracci 2, 53100 Siena, Italy. Electronic address: alessandra.renieri@unisi.it.
  • Campiani G; NatSynDrugs, Department of Biotechnology, Chemistry and Pharmacy, DoE 2018-2022 University of Siena, via Aldo Moro 2, 53100 Siena, Italy. Electronic address: campiani@unisi.it.
  • Meloni I; Medical Genetics, University of Siena, Strada delle Scotte 4, 53100, Siena, Italy.
Exp Cell Res ; 368(2): 225-235, 2018 07 15.
Article en En | MEDLINE | ID: mdl-29730163
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tubulina (Proteína) / Síndrome de Rett / Células Madre Pluripotentes Inducidas / Neuronas GABAérgicas / Histona Desacetilasa 6 Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Exp Cell Res Año: 2018 Tipo del documento: Article País de afiliación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tubulina (Proteína) / Síndrome de Rett / Células Madre Pluripotentes Inducidas / Neuronas GABAérgicas / Histona Desacetilasa 6 Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Exp Cell Res Año: 2018 Tipo del documento: Article País de afiliación: Italia