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Effects of valproate on brain volumes in pediatric bipolar disorder: A preliminary study.
Cazala, Fadwa; Suchting, Robert; Zeni, Cristian P; Bauer, Isabelle E; Mwangi, Benson; Wu, Mon-Ju; Passos, Ives Cavalcante; Spiker, Danielle E; Zunta-Soares, Giovanna B; Soares, Jair C.
Afiliación
  • Cazala F; School of Medicine, The University of Texas Health Science Center at Houston, USA. Electronic address: fadwa.cazala@gmail.com.
  • Suchting R; School of Medicine, The University of Texas Health Science Center at Houston, USA.
  • Zeni CP; School of Medicine, The University of Texas Health Science Center at Houston, USA.
  • Bauer IE; School of Medicine, The University of Texas Health Science Center at Houston, USA.
  • Mwangi B; School of Medicine, The University of Texas Health Science Center at Houston, USA.
  • Wu MJ; School of Medicine, The University of Texas Health Science Center at Houston, USA.
  • Passos IC; Department of Psychiatry, Laboratory of Molecular Psychiatry, Universidade Federal do Rio Grande do Sul (UFRGS), Brazil.
  • Spiker DE; School of Medicine, The University of Texas Health Science Center at Houston, USA.
  • Zunta-Soares GB; School of Medicine, The University of Texas Health Science Center at Houston, USA.
  • Soares JC; School of Medicine, The University of Texas Health Science Center at Houston, USA.
Psychiatry Res Neuroimaging ; 278: 65-68, 2018 08 30.
Article en En | MEDLINE | ID: mdl-29907438
ABSTRACT
Sodium valproate (VPA) has well-established neuroprotective effects and is recommended as treatment in bipolar disorder patients. The neural effects of VPA in pediatric bipolar disorder (PBD) have yet to be established. This preliminary study explored the effects of VPA on brain structure in PBD. Fourteen PBD patients (10 males; mean = 13.43 ± 3.05 years old) underwent a structural MRI before and after a 6-week VPA treatment period. Bayesian linear mixed modeling explored seven brain region volumes as a function of dichotomous pre/post time. Results showed a decrease in amygdala volume over time. These findings need to be confirmed by large-scale, longitudinal studies.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastorno Bipolar / Encéfalo / Ácido Valproico Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastorno Bipolar / Encéfalo / Ácido Valproico Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2018 Tipo del documento: Article