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Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.
Petrie, Emma J; Sandow, Jarrod J; Jacobsen, Annette V; Smith, Brian J; Griffin, Michael D W; Lucet, Isabelle S; Dai, Weiwen; Young, Samuel N; Tanzer, Maria C; Wardak, Ahmad; Liang, Lung-Yu; Cowan, Angus D; Hildebrand, Joanne M; Kersten, Wilhelmus J A; Lessene, Guillaume; Silke, John; Czabotar, Peter E; Webb, Andrew I; Murphy, James M.
Afiliación
  • Petrie EJ; The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. petrie.e@wehi.edu.au.
  • Sandow JJ; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. petrie.e@wehi.edu.au.
  • Jacobsen AV; The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Smith BJ; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.
  • Griffin MDW; The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Lucet IS; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.
  • Dai W; Department of Biochemistry & Molecular Biology, LaTrobe University, Bundoora, VIC, Australia.
  • Young SN; Department of Biochemistry & Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, The Bio21 Institute, Parkville, VIC, Australia.
  • Tanzer MC; The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Wardak A; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.
  • Liang LY; The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Cowan AD; The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Hildebrand JM; The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Kersten WJA; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.
  • Lessene G; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Bavaria, Germany.
  • Silke J; The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Czabotar PE; The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Webb AI; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.
  • Murphy JM; The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Nat Commun ; 9(1): 2422, 2018 06 21.
Article en En | MEDLINE | ID: mdl-29930286

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Quinasas / Modelos Moleculares / Muerte Celular Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Australia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Quinasas / Modelos Moleculares / Muerte Celular Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Australia