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Efficient Industrial Synthesis of the MDM2 Antagonist Idasanutlin via a Cu(I)-catalyzed [3+2] Asymmetric Cycloaddition.
Fishlock, Dan; Diodone, Ralph; Hildbrand, Stefan; Kuhn, Bernd; Mössner, Christian; Peters, Carsten; Rege, Pankaj D; Rimmler, Gösta; Schantz, Markus.
Afiliación
  • Fishlock D; Process Chemistry and Catalysis Small Molecule Technical Development F. Hoffmann-La Roche, CH-4070 Basel;, Email: daniel.fishlock@roche.com.
  • Diodone R; Process Chemistry and Catalysis Small Molecule Technical Development F. Hoffmann-La Roche, CH-4070 Basel.
  • Hildbrand S; Process Chemistry and Catalysis Small Molecule Technical Development F. Hoffmann-La Roche, CH-4070 Basel.
  • Kuhn B; Contributions to computational chemistry and modelling Computer-aided Drug Design Group Pharmaceutical Research and Early Development F. Hoffmann-La Roche, CH-4070 Basel.
  • Mössner C; Process Chemistry and Catalysis Small Molecule Technical Development F. Hoffmann-La Roche, CH-4070 Basel.
  • Peters C; Process Chemistry and Catalysis Small Molecule Technical Development F. Hoffmann-La Roche, CH-4070 Basel.
  • Rege PD; Process Chemistry and Catalysis Small Molecule Technical Development F. Hoffmann-La Roche, CH-4070 Basel.
  • Rimmler G; Process Chemistry and Catalysis Small Molecule Technical Development F. Hoffmann-La Roche, CH-4070 Basel.
  • Schantz M; Process Chemistry and Catalysis Small Molecule Technical Development F. Hoffmann-La Roche, CH-4070 Basel.
Chimia (Aarau) ; 72(7): 492-500, 2018 Aug 22.
Article en En | MEDLINE | ID: mdl-30158012
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirrolidinas / Proteínas Proto-Oncogénicas c-mdm2 / Para-Aminobenzoatos Idioma: En Revista: Chimia (Aarau) Año: 2018 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirrolidinas / Proteínas Proto-Oncogénicas c-mdm2 / Para-Aminobenzoatos Idioma: En Revista: Chimia (Aarau) Año: 2018 Tipo del documento: Article