Expanded disability status scale progression assessment heterogeneity in multiple sclerosis according to geographical areas.
Ann Neurol
; 84(4): 621-625, 2018 10.
Article
en En
| MEDLINE
| ID: mdl-30179270
ABSTRACT
Using placebo data from 3 randomized multiple sclerosis (MS) trials with uniform inclusion criteria, we investigated heterogeneity of Expanded Disability Status Scale (EDSS) progression by geographical areas. Our analysis revealed a significantly lower EDSS progression in Eastern European countries (10.8%) compared with Western Europe (13.1%) or the USA/Canada (21.4%, p < 0.001); EDSS improvement behaved the same way. This heterogeneity is not explained by differences of baseline variables. No differences were detected on more easily quantifiable measures, the Timed 25-Foot Walk or the Multiple Sclerosis Functional Composite. At a time when disease progression represents the target for future interventions in MS, establishment of more quantitative and objective outcomes remains a key priority of MS research. Ann Neurol 2018;84621-625.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Progresión de la Enfermedad
/
Evaluación de la Discapacidad
/
Esclerosis Múltiple
Tipo de estudio:
Clinical_trials
/
Systematic_reviews
Límite:
Humans
País/Región como asunto:
America do norte
/
Europa
Idioma:
En
Revista:
Ann Neurol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Italia