Methylation of Structured RNA by the m<sup>6</sup>A Writer METTL16 Is Essential for Mouse Embryonic Development.

Mendel, Mateusz; Chen, Kuan-Ming; Homolka, David; Gos, Pascal; Pandey, Radha Raman; McCarthy, Andrew A; Pillai, Ramesh S

Methylation of Structured RNA by the m⁶A Writer METTL16 Is Essential for Mouse Embryonic Development.

Mendel, Mateusz; Chen, Kuan-Ming; Homolka, David; Gos, Pascal; Pandey, Radha Raman; McCarthy, Andrew A; Pillai, Ramesh S.

Afiliación

Mendel M; Department of Molecular Biology, Science III, University of Geneva, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland.
Chen KM; Department of Molecular Biology, Science III, University of Geneva, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland.
Homolka D; Department of Molecular Biology, Science III, University of Geneva, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland.
Gos P; Department of Molecular Biology, Science III, University of Geneva, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland.
Pandey RR; Department of Molecular Biology, Science III, University of Geneva, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland.
McCarthy AA; European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, 38042 Grenoble, France.
Pillai RS; Department of Molecular Biology, Science III, University of Geneva, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland. Electronic address: ramesh.pillai@unige.ch.

Mol Cell ; 71(6): 986-1000.e11, 2018 09 20.

Article en En | MEDLINE | ID: mdl-30197299

Asunto(s)

Adenosina/análogos & derivados; Metiltransferasas/metabolismo; Metiltransferasas/ultraestructura; Adenosina/metabolismo; Animales; Desmetilación; Desarrollo Embrionario/genética; Desarrollo Embrionario/fisiología; Expresión Génica/genética; Células HEK293; Humanos; Metionina Adenosiltransferasa; Metilación; Metiltransferasas/fisiología; Ratones/embriología; Ratones Noqueados; ARN; Procesamiento Postranscripcional del ARN/fisiología; ARN Mensajero/metabolismo; ARN Nuclear Pequeño/metabolismo

Palabras clave

METTL16; Mat2a; SAM availability; SAM synthetase; U6 snRNA; blastocysts; crystal structure; m(6)A; morula; splicing

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Adenosina / Metiltransferasas Límite: Animals / Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: Suiza

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