Discovery and anti-inflammatory evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3ß (GSK-3ß).

Gao, Yang; Zhang, Peng; Cui, Anfeng; Ye, De-Yong; Xiang, Meng; Chu, Yong

Gao, Yang; Zhang, Peng; Cui, Anfeng; Ye, De-Yong; Xiang, Meng; Chu, Yong.

Afiliación

Gao Y; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China; State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, Shanghai 201203, China.
Zhang P; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China; State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, Shanghai 201203, China.
Cui A; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Ye DY; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
Xiang M; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China. Electronic address: xmeng@shmu.edu.cn.
Chu Y; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address: cy110@fudan.edu.cn.

Bioorg Med Chem ; 26(20): 5479-5493, 2018 11 01.

Article en En | MEDLINE | ID: mdl-30293796

Asunto(s)

Lesión Pulmonar Aguda/tratamiento farmacológico; Antiinflamatorios/química; Antiinflamatorios/uso terapéutico; Glucógeno Sintasa Quinasa 3 beta/antagonistas & inhibidores; Inhibidores de Proteínas Quinasas/química; Inhibidores de Proteínas Quinasas/uso terapéutico; Tiazepinas/química; Tiazepinas/uso terapéutico; Lesión Pulmonar Aguda/inmunología; Lesión Pulmonar Aguda/patología; Animales; Antiinflamatorios/farmacología; Cristalografía por Rayos X; Descubrimiento de Drogas; Glucógeno Sintasa Quinasa 3 beta/inmunología; Humanos; Masculino; Ratones Endogámicos C57BL; Simulación del Acoplamiento Molecular; Inhibidores de Proteínas Quinasas/farmacología; Tiazepinas/farmacología

Palabras clave

Benzothiazepinones; Glycogen synthase kinase 3ß; Inflammation; Non-ATP competitive inhibitors; Sirtuin 1

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tiazepinas / Inhibidores de Proteínas Quinasas / Lesión Pulmonar Aguda / Glucógeno Sintasa Quinasa 3 beta / Antiinflamatorios Límite: Animals / Humans / Male Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: China

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