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Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders.
Rageot, Denise; Bohnacker, Thomas; Melone, Anna; Langlois, Jean-Baptiste; Borsari, Chiara; Hillmann, Petra; Sele, Alexander M; Beaufils, Florent; Zvelebil, Marketa; Hebeisen, Paul; Löscher, Wolfgang; Burke, John; Fabbro, Doriano; Wymann, Matthias P.
Afiliación
  • Rageot D; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • Bohnacker T; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • Melone A; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • Langlois JB; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • Borsari C; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • Hillmann P; PIQUR Therapeutics AG , Hochbergerstrasse 60 , 4057 Basel , Switzerland.
  • Sele AM; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • Beaufils F; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • Zvelebil M; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
  • Hebeisen P; PIQUR Therapeutics AG , Hochbergerstrasse 60 , 4057 Basel , Switzerland.
  • Löscher W; Department of Pharmacology, Toxicology, and Pharmacy , University of Veterinary Medicine Hannover, and Center for Systems Neuroscience , 30559 Hannover , Germany.
  • Burke J; Department of Biochemistry and Microbiology , University of Victoria , Victoria , British Columbia V8W 2Y2 , Canada.
  • Fabbro D; PIQUR Therapeutics AG , Hochbergerstrasse 60 , 4057 Basel , Switzerland.
  • Wymann MP; Department of Biomedicine , University of Basel , Mattenstrasse 28 , 4058 Basel , Switzerland.
J Med Chem ; 61(22): 10084-10105, 2018 11 21.
Article en En | MEDLINE | ID: mdl-30359003
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Convulsiones / Triazinas / Compuestos de Azabiciclo / Diana Mecanicista del Complejo 1 de la Rapamicina / Diana Mecanicista del Complejo 2 de la Rapamicina Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Convulsiones / Triazinas / Compuestos de Azabiciclo / Diana Mecanicista del Complejo 1 de la Rapamicina / Diana Mecanicista del Complejo 2 de la Rapamicina Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Suiza