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The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease.
Noronha, Alberto; Modamio, Jennifer; Jarosz, Yohan; Guerard, Elisabeth; Sompairac, Nicolas; Preciat, German; Daníelsdóttir, Anna Dröfn; Krecke, Max; Merten, Diane; Haraldsdóttir, Hulda S; Heinken, Almut; Heirendt, Laurent; Magnúsdóttir, Stefanía; Ravcheev, Dmitry A; Sahoo, Swagatika; Gawron, Piotr; Friscioni, Lucia; Garcia, Beatriz; Prendergast, Mabel; Puente, Alberto; Rodrigues, Mariana; Roy, Akansha; Rouquaya, Mouss; Wiltgen, Luca; Zagare, Alise; John, Elisabeth; Krueger, Maren; Kuperstein, Inna; Zinovyev, Andrei; Schneider, Reinhard; Fleming, Ronan M T; Thiele, Ines.
Afiliación
  • Noronha A; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Modamio J; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Jarosz Y; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Guerard E; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Sompairac N; Institut Curie, PSL Research University, INSERM U900, F-75005 Paris, France and CBIO-Centre for Computational Biology, MINES ParisTech, PSL Research University, F-75006 Paris, France.
  • Preciat G; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Daníelsdóttir AD; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Krecke M; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Merten D; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Haraldsdóttir HS; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Heinken A; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Heirendt L; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Magnúsdóttir S; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Ravcheev DA; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Sahoo S; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Gawron P; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Friscioni L; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Garcia B; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Prendergast M; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Puente A; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Rodrigues M; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Roy A; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Rouquaya M; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Wiltgen L; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Zagare A; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • John E; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Krueger M; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Kuperstein I; Institut Curie, PSL Research University, INSERM U900, F-75005 Paris, France and CBIO-Centre for Computational Biology, MINES ParisTech, PSL Research University, F-75006 Paris, France.
  • Zinovyev A; Institut Curie, PSL Research University, INSERM U900, F-75005 Paris, France and CBIO-Centre for Computational Biology, MINES ParisTech, PSL Research University, F-75006 Paris, France.
  • Schneider R; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Fleming RMT; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette L-4367, Luxembourg.
  • Thiele I; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Faculty of Science, University of Leiden, Leiden 2333, The Netherlands.
Nucleic Acids Res ; 47(D1): D614-D624, 2019 01 08.
Article en En | MEDLINE | ID: mdl-30371894
ABSTRACT
A multitude of factors contribute to complex diseases and can be measured with 'omics' methods. Databases facilitate data interpretation for underlying mechanisms. Here, we describe the Virtual Metabolic Human (VMH, www.vmh.life) database encapsulating current knowledge of human metabolism within five interlinked resources 'Human metabolism', 'Gut microbiome', 'Disease', 'Nutrition', and 'ReconMaps'. The VMH captures 5180 unique metabolites, 17 730 unique reactions, 3695 human genes, 255 Mendelian diseases, 818 microbes, 632 685 microbial genes and 8790 food items. The VMH's unique features are (i) the hosting of the metabolic reconstructions of human and gut microbes amenable for metabolic modeling; (ii) seven human metabolic maps for data visualization; (iii) a nutrition designer; (iv) a user-friendly webpage and application-programming interface to access its content; (v) user feedback option for community engagement and (vi) the connection of its entities to 57 other web resources. The VMH represents a novel, interdisciplinary database for data interpretation and hypothesis generation to the biomedical community.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Genómica / Bases de Datos Genéticas / Metaboloma / Metabolómica / Microbioma Gastrointestinal Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nucleic Acids Res Año: 2019 Tipo del documento: Article País de afiliación: Luxemburgo
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Genómica / Bases de Datos Genéticas / Metaboloma / Metabolómica / Microbioma Gastrointestinal Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nucleic Acids Res Año: 2019 Tipo del documento: Article País de afiliación: Luxemburgo