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Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis.
Henstridge, Christopher M; Hyman, Bradley T; Spires-Jones, Tara L.
Afiliación
  • Henstridge CM; The University of Edinburgh Centre for Discovery Brain Sciences, UK Dementia Research Institute, Edinburgh, UK.
  • Hyman BT; MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
  • Spires-Jones TL; The University of Edinburgh Centre for Discovery Brain Sciences, UK Dementia Research Institute, Edinburgh, UK. tara.spires-jones@ed.ac.uk.
Nat Rev Neurosci ; 20(2): 94-108, 2019 02.
Article en En | MEDLINE | ID: mdl-30643230
The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but neurons do not work in isolation. Emerging evidence suggests that the intricate balance of interactions between neurons, astrocytes, microglia and vascular cells required for healthy brain function becomes perturbed during the disease, with early changes likely protecting neural circuits from damage, followed later by harmful effects when the balance cannot be restored. Moving beyond a neuronal focus to understand the complex cellular interactions in Alzheimer disease and how these change throughout the course of the disease may provide important insight into developing effective therapeutics.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Neuronas Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Nat Rev Neurosci Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Neuronas Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Nat Rev Neurosci Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article