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MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans.
Koch, Alexander W; Schiering, Nikolaus; Melkko, Samu; Ewert, Stefan; Salter, Janeen; Zhang, Yiming; McCormack, Peter; Yu, Jianying; Huang, Xueming; Chiu, Yu-Hsin; Chen, Zhiping; Schleeger, Simone; Horny, Geraldine; DiPetrillo, Keith; Muller, Lionel; Hein, Andreas; Villard, Frederic; Scharenberg, Meike; Ramage, Paul; Hassiepen, Ulrich; Côté, Serge; DeGagne, Julie; Krantz, Carsten; Eder, Jörg; Stoll, Brian; Kulmatycki, Kenneth; Feldman, David L; Hoffmann, Peter; Basson, Craig T; Frost, Robert J A; Khder, Yasser.
Afiliación
  • Koch AW; Novartis Institutes for BioMedical Research, Cambridge, MA.
  • Schiering N; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Melkko S; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Ewert S; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Salter J; Novartis Pharmaceuticals Corporation, East Hanover, NJ.
  • Zhang Y; Novartis Pharmaceuticals Corporation, East Hanover, NJ.
  • McCormack P; Novartis Pharma AG, Basel, Switzerland; and.
  • Yu J; Novartis Institutes for BioMedical Research, Cambridge, MA.
  • Huang X; Novartis Institutes for BioMedical Research, Cambridge, MA.
  • Chiu YH; Novartis Institutes for BioMedical Research, Cambridge, MA.
  • Chen Z; Novartis Institutes for BioMedical Research, Cambridge, MA.
  • Schleeger S; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Horny G; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • DiPetrillo K; Novartis Pharmaceuticals Corporation, East Hanover, NJ.
  • Muller L; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Hein A; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Villard F; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Scharenberg M; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Ramage P; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Hassiepen U; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Côté S; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • DeGagne J; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Krantz C; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Eder J; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Stoll B; Novartis Institutes for BioMedical Research, Cambridge, MA.
  • Kulmatycki K; Novartis Institutes for BioMedical Research, Cambridge, MA.
  • Feldman DL; Novartis Institutes for BioMedical Research, Cambridge, MA.
  • Hoffmann P; Novartis Institutes for BioMedical Research, East Hanover, NJ.
  • Basson CT; Novartis Institutes for BioMedical Research, Cambridge, MA.
  • Frost RJA; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Khder Y; Novartis Institutes for BioMedical Research, Basel, Switzerland.
Blood ; 133(13): 1507-1516, 2019 03 28.
Article en En | MEDLINE | ID: mdl-30692123
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trombosis / Coagulación Sanguínea / Factor XI / Anticuerpos Monoclonales Humanizados / Anticoagulantes Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Blood Año: 2019 Tipo del documento: Article País de afiliación: Marruecos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trombosis / Coagulación Sanguínea / Factor XI / Anticuerpos Monoclonales Humanizados / Anticoagulantes Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Blood Año: 2019 Tipo del documento: Article País de afiliación: Marruecos