Galactose α-1,3-galactose phenotypes: Lessons from various patient populations.
Ann Allergy Asthma Immunol
; 122(6): 598-602, 2019 06.
Article
en En
| MEDLINE
| ID: mdl-30922956
ABSTRACT
OBJECTIVE:
To review published studies on galactose α-1,3-galactose (α-gal), a carbohydrate epitope found on proteins and lipids in nonprimate mammals and present in foods (particularly organ or fat-rich red meat) and medications, where it causes delayed-onset and immediate-onset anaphylaxis. DATA SOURCES A literature search for the terms galactose α-1,3-galactose and α-gal using PubMed and Embase was performed. STUDY SELECTIONS Studies on α-gal were included in this review.RESULTS:
Several species of ticks contain α-gal epitopes and possibly salivary adjuvants that promote high titer sensitization and clinical reactivity. Risk factors for α-gal syndrome include exposure to ticks of particular species. Age and sex differences seen in various cohorts possibly reflect the prevalence of these exposures that vary according to setting.CONCLUSION:
The reason and mechanisms for delayed onset of food-related anaphylaxis and the preponderance of abdominal reactions are not clear but may involve the kinetics of allergen digestion and processing or immunologic presentation via a different mechanism from usual immediate-type food allergy.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Alérgenos
/
Proteínas de Insectos
/
Grupos de Población
/
Hipersensibilidad a los Alimentos
/
Galactosa
/
Anafilaxia
Tipo de estudio:
Systematic_reviews
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Ann Allergy Asthma Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2019
Tipo del documento:
Article