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Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria.
Ballantine, Ross D; McCallion, Conor E; Nassour, Elie; Tokajian, Sima; Cochrane, Stephen A.
Afiliación
  • Ballantine RD; School of Chemistry and Chemical Engineering , David Keir Building , Queen's University Belfast , Stranmillis Road , Belfast , BT9 5AG , UK . Email: s.cochrane@qub.ac.uk.
  • McCallion CE; School of Chemistry and Chemical Engineering , David Keir Building , Queen's University Belfast , Stranmillis Road , Belfast , BT9 5AG , UK . Email: s.cochrane@qub.ac.uk.
  • Nassour E; Department of Natural Sciences , School of Arts and Sciences , Lebanese American University , Byblos , Lebanon.
  • Tokajian S; Department of Natural Sciences , School of Arts and Sciences , Lebanese American University , Byblos , Lebanon.
  • Cochrane SA; School of Chemistry and Chemical Engineering , David Keir Building , Queen's University Belfast , Stranmillis Road , Belfast , BT9 5AG , UK . Email: s.cochrane@qub.ac.uk.
Medchemcomm ; 10(3): 484-487, 2019 Mar 01.
Article en En | MEDLINE | ID: mdl-31015912
Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, a family of linear lipo-tridecapeptides, are easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as d/l diaminobutyric acid and d-allo-isoleucine, significantly increasing their cost of synthesis. Herein, we report a series of new tridecaptin derivatives that are much cheaper to synthesize and retain strong activity against multidrug-resistant Gram-negative bacteria.

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Medchemcomm Año: 2019 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Medchemcomm Año: 2019 Tipo del documento: Article