Modulation of 5-fluorouracil activation of toll-like/MyD88/NF-&#954;B/MAPK pathway by Saccharomyces boulardii CNCM I-745 probiotic.

Justino, Priscilla F C; Franco, Alvaro X; Pontier-Bres, Rodolphe; Monteiro, Carlos E S; Barbosa, André L R; Souza, Marcellus H L P; Czerucka, Dorota; Soares, Pedro M G

Modulation of 5-fluorouracil activation of toll-like/MyD88/NF-κB/MAPK pathway by Saccharomyces boulardii CNCM I-745 probiotic.

Justino, Priscilla F C; Franco, Alvaro X; Pontier-Bres, Rodolphe; Monteiro, Carlos E S; Barbosa, André L R; Souza, Marcellus H L P; Czerucka, Dorota; Soares, Pedro M G.

Afiliación

Justino PFC; LEFFAG - Laboratory of Physiopharmacology Study of Gastrointestinal Tract, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Franco AX; LEFFAG - Laboratory of Physiopharmacology Study of Gastrointestinal Tract, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Pontier-Bres R; Centre Scientifique de Monaco, 8 quai Antoine 1er, MC98000, Monaco.
Monteiro CES; LEFFAG - Laboratory of Physiopharmacology Study of Gastrointestinal Tract, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Barbosa ALR; LAFFEX - Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research, Federal University of Piauí, Parnaíba, Brazil.
Souza MHLP; LEFFAG - Laboratory of Physiopharmacology Study of Gastrointestinal Tract, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Czerucka D; Centre Scientifique de Monaco, 8 quai Antoine 1er, MC98000, Monaco.
Soares PMG; LEFFAG - Laboratory of Physiopharmacology Study of Gastrointestinal Tract, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil; Department of Morphology, Medical School, Federal University of Ceara, Rua Delmiro de Farias s/n, Rodolfo Teofilo, Fortaleza, Cear

Cytokine ; 125: 154791, 2020 01.

Article en En | MEDLINE | ID: mdl-31401369

Asunto(s)

Citocinas/metabolismo; Fluorouracilo/farmacología; Mucositis/metabolismo; Factor 88 de Diferenciación Mieloide/metabolismo; FN-kappa B/metabolismo; Probióticos/farmacología; Saccharomyces boulardii/metabolismo; Receptores Toll-Like/metabolismo; Animales; Células CACO-2; Quimiocina CXCL1/genética; Quimiocina CXCL1/metabolismo; Citocinas/genética; Fluorouracilo/efectos adversos; Humanos; Íleon/metabolismo; Inmunohistoquímica; Inflamación/metabolismo; Interleucina-1beta/genética; Quinasas Janus/metabolismo; Yeyuno/metabolismo; Lipopolisacáridos/farmacología; Sistema de Señalización de MAP Quinasas/efectos de los fármacos; Sistema de Señalización de MAP Quinasas/genética; Masculino; Ratones; Mucositis/tratamiento farmacológico; Fosforilación; Probióticos/administración & dosificación; Receptor Toll-Like 2/genética; Receptor Toll-Like 2/metabolismo; Receptor Toll-Like 4/genética; Receptor Toll-Like 4/metabolismo; Receptores Toll-Like/genética; Factor de Necrosis Tumoral alfa/genética; Factor de Necrosis Tumoral alfa/metabolismo; Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo

Palabras clave

Inflammatory pathways; Mucositis; Probiotics; Side effects

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Citocinas / FN-kappa B / Probióticos / Mucositis / Receptores Toll-Like / Factor 88 de Diferenciación Mieloide / Fluorouracilo / Saccharomyces boulardii Límite: Animals / Humans / Male Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Brasil

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google