Human <i>GNPTAB</i> stuttering mutations engineered into mice cause vocalization deficits and astrocyte pathology in the corpus callosum.

Han, Tae-Un; Root, Jessica; Reyes, Laura D; Huchinson, Elizabeth B; Hoffmann, Johann du; Lee, Wang-Sik; Barnes, Terra D; Drayna, Dennis

Human GNPTAB stuttering mutations engineered into mice cause vocalization deficits and astrocyte pathology in the corpus callosum.

Han, Tae-Un; Root, Jessica; Reyes, Laura D; Huchinson, Elizabeth B; Hoffmann, Johann du; Lee, Wang-Sik; Barnes, Terra D; Drayna, Dennis.

Afiliación

Han TU; Section on Genetics of Communication Disorders, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892.
Root J; Section on Genetics of Communication Disorders, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892.
Reyes LD; Section on Quantitative Medical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892.
Huchinson EB; Section on Quantitative Medical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892.
Hoffmann JD; Section on Behavioral Neuroscience, Rodent Behavioral Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892.
Lee WS; Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.
Barnes TD; Department of Neuroscience, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.
Drayna D; Section on Genetics of Communication Disorders, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892; drayna@nidcd.nih.gov.

Proc Natl Acad Sci U S A ; 116(35): 17515-17524, 2019 08 27.

Article en En | MEDLINE | ID: mdl-31405983

Asunto(s)

Astrocitos/metabolismo; Cuerpo Calloso/metabolismo; Mutación; Tartamudeo/genética; Transferasas (Grupos de Otros Fosfatos Sustitutos)/genética; Vocalización Animal; Animales; Recuento de Células; Modelos Animales de Enfermedad; Humanos; Masculino; Ratones; Ratones Transgénicos; Fenotipo; Hidrolasas Diéster Fosfóricas/sangre

Palabras clave

Cre-drivers; astrocytes; mouse vocalization; stuttering; white matter

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tartamudeo / Vocalización Animal / Astrocitos / Transferasas (Grupos de Otros Fosfatos Sustitutos) / Cuerpo Calloso / Mutación Límite: Animals / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article

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