DNA damage and hormone-related cancer: a repair pathway view.
Hum Mol Genet
; 28(R2): R180-R186, 2019 11 21.
Article
en En
| MEDLINE
| ID: mdl-31435665
ABSTRACT
In this short review, we examine the overlap between genes known to be mutated in the germlines of individuals at risk of breast, ovarian and prostate cancers, and their positions in DNA damage repair pathways. Cancer risk mutations have been consistently reported in certain genes at the top of these pathways, but none have been reported in others. We consider whether some of these gene products are too crucial to life for mutations to be tolerated, whilst others, further down the pathways, are less essential.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Neoplasias de la Mama
/
Proteína BRCA1
/
Proteína BRCA2
/
Reparación del ADN
/
Proteínas de la Ataxia Telangiectasia Mutada
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Hum Mol Genet
Asunto de la revista:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Reino Unido