Successful management of tertiary hyperparathyroidism associated with hypophosphataemic rickets in an adult.
J Musculoskelet Neuronal Interact
; 19(3): 370-373, 2019 09 01.
Article
en En
| MEDLINE
| ID: mdl-31475945
ABSTRACT
Tertiary hyperparathyroidism (THP) is a rare complication in patients with hypophosphataemic rickets (HR), usually related to long-term management with active vitamin D analogues and oral phosphate salts. If left untreated, THP may aggravate bone and renal disease. We report a case of THP, which developed during the course of HR. Preoperatively, cinacalcet administration along with gradual increase in alphacalcidol dose, led to almost normalization of serum calcium and decrease in parathyroid hormone (PTH) concentrations. The patient underwent an uneventful subtotal parathyroidectomy, resulting in PTH normalization and stabilization of eucalcaemia during 18 months of follow-up. We conclude that, except for optimal dosage of elementary phosphate and alphacalcidol, cinacalcet prior to parathyroidectomy may be an effective option in patients with HR complicated with THP.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Raquitismo Hipofosfatémico Familiar
/
Cinacalcet
/
Hormonas y Agentes Reguladores de Calcio
/
Hiperparatiroidismo Secundario
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Musculoskelet Neuronal Interact
Asunto de la revista:
FISIOLOGIA
/
NEUROLOGIA
/
ORTOPEDIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Grecia