A versatile theranostic nanodevice based on an orthogonal bioconjugation strategy for efficient targeted treatment and monitoring of triple negative breast cancer.

Cano-Cortes, María Victoria; Navarro-Marchal, Saúl Abenhamar; Ruiz-Blas, María Paz; Diaz-Mochon, Juan José; Marchal, Juan Antonio; Sanchez-Martin, Rosario M

Cano-Cortes, María Victoria; Navarro-Marchal, Saúl Abenhamar; Ruiz-Blas, María Paz; Diaz-Mochon, Juan José; Marchal, Juan Antonio; Sanchez-Martin, Rosario M.

Afiliación

Cano-Cortes MV; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain; Department of Medicinal & Organic Chemistry and Excellence Research Unit of "Chemistry applied to Biomedicine and the Environment," Faculty of Pharmacy,
Navarro-Marchal SA; Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research (CIBM), University of Granada, Granada, Spain; Department of Applied Physics, Faculty of Sciences, University of Granada, Granada, Spain; Department of Human Anatomy and Embryology and Excellence Research Unit
Ruiz-Blas MP; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain; Department of Medicinal & Organic Chemistry and Excellence Research Unit of "Chemistry applied to Biomedicine and the Environment," Faculty of Pharmacy,
Diaz-Mochon JJ; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain; Department of Medicinal & Organic Chemistry and Excellence Research Unit of "Chemistry applied to Biomedicine and the Environment," Faculty of Pharmacy,
Marchal JA; Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research (CIBM), University of Granada, Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Universidad de Granada, Granada, Spain; Department of Human Anatomy and Embryology and Excellence
Sanchez-Martin RM; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain; Department of Medicinal & Organic Chemistry and Excellence Research Unit of "Chemistry applied to Biomedicine and the Environment," Faculty of Pharmacy,

Nanomedicine ; 24: 102120, 2020 02.

Article en En | MEDLINE | ID: mdl-31676374

Asunto(s)

Carbocianinas; Doxorrubicina; Sistemas de Liberación de Medicamentos; Nanopartículas; Péptidos; Nanomedicina Teranóstica; Neoplasias de la Mama Triple Negativas/tratamiento farmacológico; Animales; Carbocianinas/química; Carbocianinas/farmacología; Línea Celular Tumoral; Doxorrubicina/química; Doxorrubicina/farmacología; Femenino; Humanos; Ratones; Ratones Endogámicos NOD; Ratones SCID; Nanopartículas/química; Nanopartículas/uso terapéutico; Proteínas de Neoplasias/metabolismo; Neuropilina-1/metabolismo; Péptidos/química; Péptidos/farmacología; Neoplasias de la Mama Triple Negativas/metabolismo; Neoplasias de la Mama Triple Negativas/patología; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

CRGDK targeting; Covalent conjugation; Doxorubicin; Multifunctional theranostic nanodevice; Orthogonal chemistry; Polymeric nanoparticles

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Péptidos / Carbocianinas / Doxorrubicina / Sistemas de Liberación de Medicamentos / Nanopartículas / Neoplasias de la Mama Triple Negativas / Nanomedicina Teranóstica Límite: Animals / Female / Humans Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2020 Tipo del documento: Article

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