Your browser doesn't support javascript.
loading
Cerebellar volume loss in radiologically isolated syndrome.
George, Ilena C; El Mendili, Mohamed Mounir; Inglese, Matilde; Azevedo, Christina J; Kantarci, Orhun; Lebrun, Christine; Siva, Aksel; Okuda, Darin T; Pelletier, Daniel.
Afiliación
  • George IC; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • El Mendili MM; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Inglese M; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA/Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy/IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Azevedo CJ; Department of Neurology, University of Southern California, Los Angeles, CA, USA.
  • Kantarci O; Mayo Clinic, Rochester, MN, USA.
  • Lebrun C; Service de Neurologie, Hôpital Pasteur 2, Université Nice Côté d'Azur, Nice, France.
  • Siva A; Department of Neurology, Cerrahpasa School of Medicine, University of Istanbul, Istanbul, Turkey.
  • Okuda DT; UT Southwestern Medical Center, Dallas, TX, USA.
  • Pelletier D; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Neuro-Immunology Division and USC Multiple Sclerosis Comprehensive Care Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Mult Scler ; 27(1): 130-133, 2021 01.
Article en En | MEDLINE | ID: mdl-31680617
ABSTRACT
Radiologically isolated syndrome (RIS), in which asymptomatic demyelinating-appearing lesions are detected incidentally on MRI, can be a pre-clinical form of multiple sclerosis (MS). In this study, we measured cerebellar volumes on 3D T1-weighted 3T MR images in 21 individuals with RIS and 38 age- and sex-matched healthy controls (HC). Normalized cerebellar white matter volume and the anterior cerebellar gray matter volume were significantly decreased in RIS compared to HC (p = 0.003 and p = 0.005, respectively). Our findings support reports of regional brain atrophy in RIS prior to the development of a seminal attack related to inflammatory demyelination.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Desmielinizantes / Sustancia Blanca / Esclerosis Múltiple Límite: Humans Idioma: En Revista: Mult Scler Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Desmielinizantes / Sustancia Blanca / Esclerosis Múltiple Límite: Humans Idioma: En Revista: Mult Scler Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos