Effects of maternal-fetal transmission of viruses and other environmental agents on lung development.
Pediatr Res
; 87(2): 420-426, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-31698410
ABSTRACT
New information is emerging concerning the influence of environmental factors (e.g., viruses, pollutants, nutrients) on fetal lung development and the prenatal modulation of cellular and molecular effectors essential to the control of airway function, which may shed new light into the pathogenesis of chronic obstructive pulmonary disease in childhood. In particular, recent studies have shown that nanosize biological and inorganic particles (e.g., respiratory viruses and pollutants) are able to spread hematogenously across the placenta from mother to offspring and interfere with lung development during critical "windows of opportunity". Furthermore, the nutritional balance of maternal diet during pregnancy can affect postnatal lung structure and function. Adverse prenatal environmental conditions can predispose to increased airway reactivity by inducing aberrant cholinergic innervation of the respiratory tract, enhanced contractility of the airway smooth muscle, and impaired innate immunity. Such changes can persist long after birth and might provide a plausible explanation to the development of chronic airway dysfunction in children, even in the absence of atopic predisposition. Insight into maternal-fetal interactions will contribute to a better understanding of the pathogenesis of highly prevalent diseases like bronchiolitis and asthma, and may lead to more precise preventative and therapeutic strategies, or new indications for existing ones.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
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Infecciones del Sistema Respiratorio
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Virosis
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Transmisión Vertical de Enfermedad Infecciosa
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Dieta
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Contaminantes Ambientales
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Pulmón
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Enfermedades Pulmonares
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Intercambio Materno-Fetal
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Animals
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Pediatr Res
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos