Rapid, complete and sustained tumour response to the TRK inhibitor larotrectinib in an infant with recurrent, chemotherapy-refractory infantile fibrosarcoma carrying the characteristic ETV6-NTRK3 gene fusion.

Bielack, S S; Cox, M C; Nathrath, M; Apel, K; Blattmann, C; Holl, T; Jenewein, R; Klenk, U; Klothaki, P; Müller-Abt, P; Ortega-Lawerenz, S; Reynolds, M; Scheer, M; Simon-Klingenstein, K; Stegmaier, S; Tupper, R; Vokuhl, C; von Kalle, T

Bielack, S S; Cox, M C; Nathrath, M; Apel, K; Blattmann, C; Holl, T; Jenewein, R; Klenk, U; Klothaki, P; Müller-Abt, P; Ortega-Lawerenz, S; Reynolds, M; Scheer, M; Simon-Klingenstein, K; Stegmaier, S; Tupper, R; Vokuhl, C; von Kalle, T.

Afiliación

Bielack SS; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
Cox MC; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.
Nathrath M; Loxo Oncology, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, USA.
Apel K; Department of Pediatric Hematology and Oncology, Klinikum Kassel, Kassel.
Blattmann C; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
Holl T; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
Jenewein R; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
Klenk U; Radiologic Institute, Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
Klothaki P; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
Müller-Abt P; Department of Pediatric Hematology and Oncology, Klinikum Kassel, Kassel.
Ortega-Lawerenz S; Radiologic Institute, Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
Reynolds M; Institute for Pediatric Radiology, Klinikum Kassel, Kassel.
Scheer M; Loxo Oncology, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, USA.
Simon-Klingenstein K; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
Stegmaier S; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
Tupper R; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
Vokuhl C; Loxo Oncology, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, USA.
von Kalle T; Institute of Pathology - Section Pediatric Pathology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Ann Oncol ; 30(Suppl_8): viii31-viii35, 2019 11 01.

Article en En | MEDLINE | ID: mdl-31738425

Asunto(s)

Fibrosarcoma/tratamiento farmacológico; Recurrencia Local de Neoplasia/tratamiento farmacológico; Proteínas de Fusión Oncogénica/genética; Pirazoles/administración & dosificación; Pirimidinas/administración & dosificación; Neoplasias de la Lengua/tratamiento farmacológico; Neoplasias de la Lengua/genética; Fibrosarcoma/enzimología; Fibrosarcoma/genética; Fibrosarcoma/patología; Humanos; Lactante; Masculino; Recurrencia Local de Neoplasia/enzimología; Recurrencia Local de Neoplasia/genética; Recurrencia Local de Neoplasia/patología; Inhibidores de Proteínas Quinasas/administración & dosificación; Proteínas Quinasas/metabolismo; Neoplasias de la Lengua/enzimología; Neoplasias de la Lengua/patología

Palabras clave

infantile fibrosarcoma; larotrectinib; tropomyosin receptor kinase inhibition

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Neoplasias de la Lengua / Proteínas de Fusión Oncogénica / Fibrosarcoma / Recurrencia Local de Neoplasia Límite: Humans / Infant / Male Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article

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