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Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation.
Stevens, Alexandra M; Xiang, Michael; Heppler, Lisa N; Tosic, Isidora; Jiang, Kevin; Munoz, Jaime O; Gaikwad, Amos S; Horton, Terzah M; Long, Xin; Narayanan, Padmini; Seashore, Elizabeth L; Terrell, Maci C; Rashid, Raushan; Krueger, Michael J; Mangubat-Medina, Alicia E; Ball, Zachary T; Sumazin, Pavel; Walker, Sarah R; Hamada, Yoshimasa; Oyadomari, Seiichi; Redell, Michele S; Frank, David A.
Afiliación
  • Stevens AM; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
  • Xiang M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Heppler LN; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Tosic I; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Jiang K; Department of Biochemistry, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
  • Munoz JO; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Gaikwad AS; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
  • Horton TM; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
  • Long X; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
  • Narayanan P; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
  • Seashore EL; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
  • Terrell MC; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
  • Rashid R; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
  • Krueger MJ; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
  • Mangubat-Medina AE; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
  • Ball ZT; Department of Chemistry, Rice University, Houston, TX.
  • Sumazin P; Department of Chemistry, Rice University, Houston, TX.
  • Walker SR; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
  • Hamada Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Oyadomari S; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and.
  • Redell MS; Division of Molecular Biology, Institute for Genome Research, and.
  • Frank DA; Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
Blood Adv ; 3(24): 4215-4227, 2019 12 23.
Article en En | MEDLINE | ID: mdl-31856268
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosforilación Oxidativa / Leucemia Mieloide Aguda / Transducción de Señal / Atovacuona Tipo de estudio: Prognostic_studies Límite: Adolescent / Animals / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Blood Adv Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosforilación Oxidativa / Leucemia Mieloide Aguda / Transducción de Señal / Atovacuona Tipo de estudio: Prognostic_studies Límite: Adolescent / Animals / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Blood Adv Año: 2019 Tipo del documento: Article