Medial prefrontal decoupling from the default mode network benefits memory.
Neuroimage
; 210: 116543, 2020 04 15.
Article
en En
| MEDLINE
| ID: mdl-31940475
ABSTRACT
In the last few years the involvement of the medial prefrontal cortex (mPFC) in memory processing has received increased attention. It has been shown to be centrally involved when we use prior knowledge (schemas) to improve learning of related material. With the mPFC also being one of the core hubs of the default mode network (DMN) and the DMN's role in memory retrieval, we decided to investigate whether the mPFC in a schema paradigm acts independent of the DMN. We tested this with data from a cross-sectional developmental study with a schema paradigm. During retrieval of schema items, the mPFC decoupled from the DMN with the degree of decoupling predicting memory performance. This finding suggests that a demand specific reconfiguration of the DMN supports schema memory. Additionally, we found that in the control condition, which relied on episodic memory, activity in the parahippocampal gyrus was positively related to memory performance. We interpret these results as a demand specific network reconfiguration of the DMN a decoupling of the mPFC to support schema memory and a decoupling of the parahippocampal gyrus facilitating episodic memory.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Recuerdo Mental
/
Asociación
/
Aprendizaje por Asociación
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Corteza Prefrontal
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Giro Parahipocampal
/
Memoria Episódica
/
Conectoma
/
Red en Modo Predeterminado
/
Red Nerviosa
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neuroimage
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2020
Tipo del documento:
Article
País de afiliación:
Países Bajos