Complexity of Neural Component of Tumor Microenvironment in Prostate Cancer.
Pathobiology
; 87(2): 87-99, 2020.
Article
en En
| MEDLINE
| ID: mdl-32045912
ABSTRACT
The tumor microenvironment (TME) plays an essential role in the development and progression of neoplasms. TME consists of the extracellular matrix and numerous specialized cells interacting with cancer cells by paracrine and autocrine mechanisms. Tumor axonogenesis and neoneurogenesis constitute a developing area of investigation. Prostate cancer (PC) is one of the most common malignancies in men worldwide. During the past years, more and more studies have shown that mechanisms leading to the development of PC are not confined only to the epithelial cancer cell, but also involve the tumor stroma. Different nerve types and neurotransmitters present within the TME are thought to be important factors in PC biology. Moreover, perineural invasion, which is a common way of PC spreading, in parallel creates the neural niche for malignant cells. Cancer neurobiology seems to have become a new discipline to explore the contribution of neoplastic cell interactions with the nervous system and the neural TME component, also to search for potential therapeutic targets in malignant tumors such as PC.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Microambiente Tumoral
/
Sistema Nervioso
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Pathobiology
Asunto de la revista:
PATOLOGIA
Año:
2020
Tipo del documento:
Article