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A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove.
Evison, Benny J; Palmer, James T; Lambert, Gilles; Treutlein, Herbert; Zeng, Jun; Nativel, Brice; Chemello, Kévin; Zhu, Qing; Wang, Jie; Teng, Yanfen; Tang, Wei; Xu, Yanfeng; Rathi, Anuj Kumar; Kumar, Sanjay; Suchowerska, Alexandra K; Parmar, Jasneet; Dixon, Ian; Kelly, Graham E; Bonnar, James.
Afiliación
  • Evison BJ; Nyrada Inc., 828 Pacific Highway, Gordon, New South Wales 2072, Australia. Electronic address: benny.evison@nyrada.com.
  • Palmer JT; Pharmaceutical Discovery Consultation, 143-145 Flannery Court, Warrandyte, Victoria 3113, Australia.
  • Lambert G; Laboratoire Inserm UMR 1188 DéTROI, Université de la Réunion Plateforme CYROI, 2 Rue Maxime Rivière, 97490 Sainte Clotilde, France.
  • Treutlein H; Sanoosa Pty. Ltd., Level 30, 35 Collins St, Melbourne, Victoria 3000, Australia.
  • Zeng J; MedChemSoft Solutions, 3 Beech Close, Ferntree Gully, Victoria 3156, Australia.
  • Nativel B; Laboratoire Inserm UMR 1188 DéTROI, Université de la Réunion Plateforme CYROI, 2 Rue Maxime Rivière, 97490 Sainte Clotilde, France.
  • Chemello K; Laboratoire Inserm UMR 1188 DéTROI, Université de la Réunion Plateforme CYROI, 2 Rue Maxime Rivière, 97490 Sainte Clotilde, France.
  • Zhu Q; ChemPartner, No. 5 Building, 998 Halei Rd, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai, China.
  • Wang J; ChemPartner, No. 5 Building, 998 Halei Rd, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai, China.
  • Teng Y; ChemPartner, No. 5 Building, 998 Halei Rd, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai, China.
  • Tang W; ChemPartner, No. 5 Building, 998 Halei Rd, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai, China.
  • Xu Y; ChemPartner, No. 5 Building, 998 Halei Rd, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai, China.
  • Rathi AK; Jubilant Chemsys Ltd., B-34, Sector-58, Noida 201301, India.
  • Kumar S; Jubilant Chemsys Ltd., B-34, Sector-58, Noida 201301, India.
  • Suchowerska AK; Nyrada Inc., 828 Pacific Highway, Gordon, New South Wales 2072, Australia.
  • Parmar J; Nyrada Inc., 828 Pacific Highway, Gordon, New South Wales 2072, Australia.
  • Dixon I; Altnia Group, 13 Fuchsia St, Blackburn, Victoria 3130, Australia.
  • Kelly GE; Nyrada Inc., 828 Pacific Highway, Gordon, New South Wales 2072, Australia.
  • Bonnar J; Nyrada Inc., 828 Pacific Highway, Gordon, New South Wales 2072, Australia.
Bioorg Med Chem ; 28(6): 115344, 2020 03 15.
Article en En | MEDLINE | ID: mdl-32051094
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptores de LDL / Bibliotecas de Moléculas Pequeñas / Inhibidores de PCSK9 Límite: Animals / Female / Humans / Male Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptores de LDL / Bibliotecas de Moléculas Pequeñas / Inhibidores de PCSK9 Límite: Animals / Female / Humans / Male Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article