Frontline treatment with the combination obinutuzumab ± chlorambucil for chronic lymphocytic leukemia outside clinical trials: Results of a multinational, multicenter study by ERIC and the Israeli CLL study group.

Herishanu, Yair; Shaulov, Adir; Fineman, Riva; Basic-Kinda, Sandra; Aviv, Ariel; Wasik-Szczepanek, Ewa; Jaksic, Ozren; Zdrenghea, Mihnea; Greenbaum, Uri; Mandac, Inga; Simkovic, Martin; Morawska, Marta; Benjamini, Ohad; Spacek, Martin; Nemets, Anatoly; Bairey, Osnat; Trentin, Livio; Ruchlemer, Rosa; Laurenti, Luca; Stanca Ciocan, Oana; Doubek, Michael; Shvidel, Lev; Dali, Nagib; Mirás, Fátima; De Meûter, Anne; Dimou, Maria; Mauro, Francesca R; Coscia, Marta; Bumbea, Horia; Szász, Róbert; Tadmor, Tamar; Gutwein, Odit; Gentile, Massimo; Scarfò, Lydia; Tedeschi, Alessandra; Sportoletti, Paolo; Gimeno Vázquez, Eva; Marquet, Juan; Assouline, Sarit; Papaioannou, Maria; Braester, Andrei; Levato, Luciano; Gregor, Michael; Rigolin, Gian M; Loscertales, Javier; Medina Perez, Angeles; Nijziel, Marten R; Popov, Viola M; Collado, Rosa; Slavutsky, Irma

Herishanu, Yair; Shaulov, Adir; Fineman, Riva; Basic-Kinda, Sandra; Aviv, Ariel; Wasik-Szczepanek, Ewa; Jaksic, Ozren; Zdrenghea, Mihnea; Greenbaum, Uri; Mandac, Inga; Simkovic, Martin; Morawska, Marta; Benjamini, Ohad; Spacek, Martin; Nemets, Anatoly; Bairey, Osnat; Trentin, Livio; Ruchlemer, Rosa; Laurenti, Luca; Stanca Ciocan, Oana; Doubek, Michael; Shvidel, Lev; Dali, Nagib; Mirás, Fátima; De Meûter, Anne; Dimou, Maria; Mauro, Francesca R; Coscia, Marta; Bumbea, Horia; Szász, Róbert; Tadmor, Tamar; Gutwein, Odit; Gentile, Massimo; Scarfò, Lydia; Tedeschi, Alessandra; Sportoletti, Paolo; Gimeno Vázquez, Eva; Marquet, Juan; Assouline, Sarit; Papaioannou, Maria; Braester, Andrei; Levato, Luciano; Gregor, Michael; Rigolin, Gian M; Loscertales, Javier; Medina Perez, Angeles; Nijziel, Marten R; Popov, Viola M; Collado, Rosa; Slavutsky, Irma.

Afiliación

Herishanu Y; Department of Hematology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Shaulov A; Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.
Fineman R; Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Basic-Kinda S; Department of Hematology, Rambam Health Care Campus, Haifa, Israel.
Aviv A; University Hospital Centre Zagreb, Zagreb, Croatia.
Wasik-Szczepanek E; Department of Hematology, HaEmek Medical Center, Afula, Israel.
Jaksic O; Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.
Zdrenghea M; Department of Hematooncology, and Bone Marrow Transplantation Medical University, Lublin, Poland.
Greenbaum U; Dubrava University Hospital, Zagreb, Croatia.
Mandac I; Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Simkovic M; Ben-Gurion University, Soroka University Medical Center, Beer Sheva, Israel.
Morawska M; Clinical Hospital Merkur, Zagreb, Croatia.
Benjamini O; University Hospital and Medical School Hradec Kralove, Hradec Kralove, Czech Republic.
Spacek M; St. John's Cancer Center, Lublin, Poland.
Nemets A; Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.
Bairey O; Hematology Division, Chaim Sheba Medical Center, Ramat Gan, Israel.
Trentin L; Charles University and General Hospital in Prague, Prague, Czech Republic.
Ruchlemer R; Barzilai University Medical Center, Ashkelon, Israel.
Laurenti L; Rabin Medical Center, Beilinson Hospital; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Stanca Ciocan O; Hematology Unit, University of Padua, Padua, Italy.
Doubek M; Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel.
Shvidel L; Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Dali N; Coltea Clinical Hospital, Bucharest, Romania.
Mirás F; Department of Internal Medicine-Hematology and Oncology, Medical Faculty of Masaryk University and University Hospital Brno, Brno, Czech Republic.
De Meûter A; Department of Hematology, Kaplan Medical Center, Rehovot, Israel.
Dimou M; Hebrew University of Jerusalem, Jerusalem, Israel.
Mauro FR; Ziv Medical Center, Safed, Israel.
Coscia M; Hospital 12 de Octubre, Madrid, Spain.
Bumbea H; Institut Jules Bordet, Brussels, Belgium.
Szász R; Hematology Section - 1st Department Of Propaedeutic Internal Medicine, Laikon Hospital, Athens, Greece.
Tadmor T; Hematology, Department of Translational and Precision Medicine, Sapienza University, Policlinico Umberto I, Rome, Italy.
Gutwein O; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Gentile M; Emergency University Clinical Hospital, Bucharest, Romania.
Scarfò L; Division of Hematology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Tedeschi A; Hematology, Bnai Zion Medical Center, Haifa, Israel.
Sportoletti P; Assaf Ha'Rofeh, Tsrifin, Israel.
Gimeno Vázquez E; Hematology Unit and Biotechnology Research Unit, A.O. of Cosenza, Cosenza, Italy.
Marquet J; Division of Experimental Oncology, IRCCS Ospedale San Raffaele, Milan, Italy.
Assouline S; Università Vita-Salute San Raffaele, Milan, Italy.
Papaioannou M; Department of Haematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Braester A; Institute of Hematology and Center for Hemato-Oncological Research, Ospedale S. Maria della Misericordia, University of Perugia, Perugia, Italy.
Levato L; Hospital del Mar, Barcelona, Spain.
Gregor M; Hematology and Hemotherapy, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Rigolin GM; Division of Hematology, Jewish General Hospital, Montreal, Quebec, Canada.
Loscertales J; First Department of Internal Medicine, Division of Haematology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Medina Perez A; Galilee Medical Center, Nahariya, Israel.
Nijziel MR; Department Hematology-Oncology, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy.
Popov VM; Division of Hematology, Cantonal Hospital of Lucerne, Lucerne, Switzerland.
Collado R; Hematology Section, Department of Medical Sciences, University of Ferrara-Azienda Ospedaliera-Universitaria di Ferrara, University of Ferrara, Ferrara, Italy.
Slavutsky I; IIS-IP, Hospital Universitario de La Princesa, Madrid, Spain.

Am J Hematol ; 95(6): 604-611, 2020 06.

Article en En | MEDLINE | ID: mdl-32096887

Asunto(s)

Protocolos de Quimioterapia Combinada Antineoplásica/administración & dosificación; Deleción Cromosómica; Cromosomas Humanos Par 17/genética; Leucemia Linfocítica Crónica de Células B; Proteína p53 Supresora de Tumor/genética; Anciano; Anciano de 80 o más Años; Anticuerpos Monoclonales Humanizados/administración & dosificación; Anticuerpos Monoclonales Humanizados/efectos adversos; Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos; Clorambucilo/administración & dosificación; Clorambucilo/efectos adversos; Supervivencia sin Enfermedad; Femenino; Humanos; Leucemia Linfocítica Crónica de Células B/tratamiento farmacológico; Leucemia Linfocítica Crónica de Células B/genética; Leucemia Linfocítica Crónica de Células B/mortalidad; Masculino; Estudios Retrospectivos; Tasa de Supervivencia

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 17 / Leucemia Linfocítica Crónica de Células B / Protocolos de Quimioterapia Combinada Antineoplásica / Proteína p53 Supresora de Tumor / Deleción Cromosómica Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Am J Hematol Año: 2020 Tipo del documento: Article País de afiliación: Israel

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