Synthesis of novel feruloyl dipeptides with proapoptotic potential against different cancer cell lines.

Hamed, Abdelaaty; Frese, Marcel; Elgaafary, Menna; Syrovets, Tatiana; Sewald, Norbert; Simmet, Thomas; Shaaban, Mohamed

Hamed, Abdelaaty; Frese, Marcel; Elgaafary, Menna; Syrovets, Tatiana; Sewald, Norbert; Simmet, Thomas; Shaaban, Mohamed.

Afiliación

Hamed A; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany; Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City-Cairo 11884, Egypt. Electronic address: abdohamed481@yahoo.com.
Frese M; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany.
Elgaafary M; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm D-89081, Germany; Department of Pharmacognosy, College of Pharmacy, Cairo University, Cairo 11562, Egypt.
Syrovets T; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm D-89081, Germany.
Sewald N; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany.
Simmet T; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm D-89081, Germany. Electronic address: thomas.simmet@uni-ulm.de.
Shaaban M; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, El-Buhouth St. 33, Dokki-Cairo 12622, Egypt. Electronic address: mshaab

Bioorg Chem ; 97: 103678, 2020 04.

Article en En | MEDLINE | ID: mdl-32120076

Asunto(s)

Antineoplásicos/química; Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Dipéptidos/química; Dipéptidos/farmacología; Animales; Antineoplásicos/síntesis química; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Embrión de Pollo; Dipéptidos/síntesis química; Diseño de Fármacos; Ensayos de Selección de Medicamentos Antitumorales; Femenino; Humanos; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Neoplasias/tratamiento farmacológico; Neoplasias/metabolismo; Neoplasias de la Mama Triple Negativas/tratamiento farmacológico; Neoplasias de la Mama Triple Negativas/metabolismo

Palabras clave

CAM xenografts; Caspase-3/7; Feruloyl-dipeptides; In vitro cytotoxicity; Mitochondrial potential; Triple negative breast cancer

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apoptosis / Dipéptidos / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article

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