GTP-binding inhibitors increase LRRK2-linked ubiquitination and Lewy body-like inclusions.

Thomas, Joseph M; Wang, Xiaobo; Guo, Gongbo; Li, Tianxia; Dai, Bingling; Nucifora, Leslie G; Nucifora, Frederick C; Liu, Zhaohui; Xue, Fengtian; Liu, Chunfeng; Ross, Christopher A; Smith, Wanli W

Thomas, Joseph M; Wang, Xiaobo; Guo, Gongbo; Li, Tianxia; Dai, Bingling; Nucifora, Leslie G; Nucifora, Frederick C; Liu, Zhaohui; Xue, Fengtian; Liu, Chunfeng; Ross, Christopher A; Smith, Wanli W.

Afiliación

Thomas JM; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Wang X; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland.
Guo G; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Li T; Institute of Neuroscience, Soochow University School of Medicine, Suzhou, China.
Dai B; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Nucifora LG; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Nucifora FC; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Liu Z; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Xue F; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Liu C; Institute of Neuroscience, Soochow University School of Medicine, Suzhou, China.
Ross CA; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland.
Smith WW; Institute of Neuroscience, Soochow University School of Medicine, Suzhou, China.

J Cell Physiol ; 235(10): 7309-7320, 2020 10.

Article en En | MEDLINE | ID: mdl-32180220

Asunto(s)

Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina/metabolismo; Cuerpos de Lewy/metabolismo; Animales; Encéfalo/efectos de los fármacos; Encéfalo/metabolismo; Encéfalo/patología; Guanosina Trifosfato/metabolismo; Células HEK293; Humanos; Cuerpos de Inclusión/metabolismo; Cuerpos de Inclusión/patología; Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina/química; Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina/genética; Cuerpos de Lewy/patología; Ratones; Ratones Endogámicos C57BL; Proteínas Mutantes/química; Proteínas Mutantes/genética; Proteínas Mutantes/metabolismo; Mutación; Enfermedad de Parkinson/genética; Enfermedad de Parkinson/metabolismo; Enfermedad de Parkinson/patología; Agregación Patológica de Proteínas/genética; Agregación Patológica de Proteínas/metabolismo; Agregación Patológica de Proteínas/patología; Unión Proteica; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Ubiquitinación

Palabras clave

GTP-binding inhibitors; LRRK2; Parkinson's disease; aggresome; protein aggregation; ubiquitination

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cuerpos de Lewy / Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Cell Physiol Año: 2020 Tipo del documento: Article

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