Systems pharmacology reveals the mechanism of activity of Ge-Gen-Qin-Lian decoction against LPS-induced acute lung injury: A novel strategy for exploring active components and effective mechanism of TCM formulae.

Ding, Zihe; Zhong, Renxing; Yang, Yanni; Xia, Tianyi; Wang, Wujing; Wang, Yi; Xing, Na; Luo, Yun; Li, Shuyuan; Shang, Lifeng; Shu, Zunpeng

Ding, Zihe; Zhong, Renxing; Yang, Yanni; Xia, Tianyi; Wang, Wujing; Wang, Yi; Xing, Na; Luo, Yun; Li, Shuyuan; Shang, Lifeng; Shu, Zunpeng.

Afiliación

Ding Z; Guangdong Standardized Processing Engineering Technology Research Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China; Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
Zhong R; Guangdong Standardized Processing Engineering Technology Research Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China; Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
Yang Y; Guangdong Standardized Processing Engineering Technology Research Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China; Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
Xia T; Guangdong Standardized Processing Engineering Technology Research Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China; Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
Wang W; Guangdong Standardized Processing Engineering Technology Research Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China; Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
Wang Y; Guangdong Standardized Processing Engineering Technology Research Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
Xing N; Guangdong Standardized Processing Engineering Technology Research Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
Luo Y; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Li S; Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
Shang L; Guangdong Fenghua Shubao Biotechnology Co., Ltd, Guangzhou, China.
Shu Z; Guangdong Standardized Processing Engineering Technology Research Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China; Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China. Electronic address: shuzunpeng2010@163.c

Pharmacol Res ; 156: 104759, 2020 06.

Article en En | MEDLINE | ID: mdl-32200026

Asunto(s)

Lesión Pulmonar Aguda/prevención & control; Antiinflamatorios/farmacología; Apoptosis/efectos de los fármacos; Medicamentos Herbarios Chinos/farmacología; Pulmón/efectos de los fármacos; Biología de Sistemas; Lesión Pulmonar Aguda/inducido químicamente; Lesión Pulmonar Aguda/genética; Lesión Pulmonar Aguda/metabolismo; Animales; Proteínas Reguladoras de la Apoptosis/genética; Proteínas Reguladoras de la Apoptosis/metabolismo; Citocinas/genética; Citocinas/metabolismo; Modelos Animales de Enfermedad; Perfilación de la Expresión Génica; Redes Reguladoras de Genes; Mediadores de Inflamación/metabolismo; Lipopolisacáridos; Pulmón/metabolismo; Pulmón/patología; Masculino; Metabolómica; Ratones Endogámicos BALB C; Fosfatidilinositol 3-Quinasa/genética; Fosfatidilinositol 3-Quinasa/metabolismo; Mapas de Interacción de Proteínas; Proteínas Proto-Oncogénicas c-akt/genética; Proteínas Proto-Oncogénicas c-akt/metabolismo; Edema Pulmonar/inducido químicamente; Edema Pulmonar/metabolismo; Edema Pulmonar/patología; Edema Pulmonar/prevención & control; Transducción de Señal; Transcriptoma

Palabras clave

Acute lung injury; Ge-Gen-Qin-Lian decoction; PI3K/Akt signaling pathway; Systems pharmacology; The gut-lung axis theory

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Apoptosis / Biología de Sistemas / Lesión Pulmonar Aguda / Pulmón / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China

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