miR-17-5p and miR-20a-5p suppress postoperative metastasis of hepatocellular carcinoma via blocking HGF/ERBB3-NF-&#954;B positive feedback loop.

Liu, Dong-Li; Lu, Li-Li; Dong, Li-Li; Liu, Yang; Bian, Xin-Yu; Lian, Bao-Feng; Xie, Lu; Wen, Duo; Gao, Dong-Mei; Ke, Ai-Wu; Fan, Jia; Wu, Wei-Zhong

miR-17-5p and miR-20a-5p suppress postoperative metastasis of hepatocellular carcinoma via blocking HGF/ERBB3-NF-κB positive feedback loop.

Liu, Dong-Li; Lu, Li-Li; Dong, Li-Li; Liu, Yang; Bian, Xin-Yu; Lian, Bao-Feng; Xie, Lu; Wen, Duo; Gao, Dong-Mei; Ke, Ai-Wu; Fan, Jia; Wu, Wei-Zhong.

Afiliación

Liu DL; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China.
Lu LL; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China.
Dong LL; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China.
Liu Y; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China.
Bian XY; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China.
Lian BF; Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai 201203, China.
Xie L; Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai 201203, China.
Wen D; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China.
Gao DM; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China.
Ke AW; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China.
Fan J; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China.
Wu WZ; Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China.

Theranostics ; 10(8): 3668-3683, 2020.

Article en En | MEDLINE | ID: mdl-32206115

Asunto(s)

Carcinoma Hepatocelular/metabolismo; Neoplasias Hepáticas/metabolismo; MicroARNs/fisiología; Metástasis de la Neoplasia; Transducción de Señal; Animales; Carcinoma Hepatocelular/cirugía; Línea Celular Tumoral; Movimiento Celular; Proliferación Celular; Estudios de Cohortes; Femenino; Regulación Neoplásica de la Expresión Génica; Hepatectomía; Factor de Crecimiento de Hepatocito/metabolismo; Humanos; Neoplasias Hepáticas/cirugía; Masculino; Ratones; Ratones Endogámicos BALB C; Persona de Mediana Edad; FN-kappa B/metabolismo; Receptor ErbB-3/metabolismo

Palabras clave

HGF/ERBB3- NF-κB feedback loop; hepatocellular carcinoma (HCC); miRNA-17-92 cluster; microenvironment remodeling; postoperative metastasis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Carcinoma Hepatocelular / MicroARNs / Neoplasias Hepáticas / Metástasis de la Neoplasia Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Theranostics Año: 2020 Tipo del documento: Article País de afiliación: China

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