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Rapid, complete and sustained tumour response to the TRK inhibitor larotrectinib in an infant with recurrent, chemotherapy-refractory infantile fibrosarcoma carrying the characteristic ETV6-NTRK3 gene fusion.
Bielack, S S; Cox, M C; Nathrath, M; Apel, K; Blattmann, C; Holl, T; Jenewein, R; Klenk, U; Klothaki, P; Müller-Abt, P; Ortega-Lawerenz, S; Reynolds, M; Scheer, M; Simon-Klingenstein, K; Stegmaier, S; Tupper, R; Vokuhl, C; von Kalle, T.
Afiliación
  • Bielack SS; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany. Electronic addre
  • Cox MC; Loxo Oncology, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, USA.
  • Nathrath M; Department of Pediatric Hematology and Oncology, Klinikum Kassel, Kassel.
  • Apel K; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
  • Blattmann C; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
  • Holl T; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
  • Jenewein R; Radiologic Institute, Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
  • Klenk U; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
  • Klothaki P; Department of Pediatric Hematology and Oncology, Klinikum Kassel, Kassel.
  • Müller-Abt P; Radiologic Institute, Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
  • Ortega-Lawerenz S; Institute for Pediatric Radiology, Klinikum Kassel, Kassel.
  • Reynolds M; Loxo Oncology, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, USA.
  • Scheer M; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
  • Simon-Klingenstein K; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
  • Stegmaier S; Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
  • Tupper R; Loxo Oncology, a wholly owned subsidiary of Eli Lilly and Company, South San Francisco, USA.
  • Vokuhl C; Institute of Pathology - Section Pediatric Pathology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
  • von Kalle T; Radiologic Institute, Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.
Ann Oncol ; 30 Suppl 8: viii31-viii35, 2019 11.
Article en En | MEDLINE | ID: mdl-32223937
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Proteínas de Fusión Oncogénica / Inhibidores de Proteínas Quinasas / Fibrosarcoma / Recurrencia Local de Neoplasia Límite: Humans / Infant / Male / Newborn Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Proteínas de Fusión Oncogénica / Inhibidores de Proteínas Quinasas / Fibrosarcoma / Recurrencia Local de Neoplasia Límite: Humans / Infant / Male / Newborn Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article