Comparison of platelet-rich plasma and inverted internal limiting membrane flap for the management of large macular holes: A pilot study.
Indian J Ophthalmol
; 68(5): 880-884, 2020 05.
Article
en En
| MEDLINE
| ID: mdl-32317470
ABSTRACT
Purpose:
To compare the safety and efficacy of 25-gauge pars plana vitrectomy (PPV) with either platelet-rich plasma (PRP) or inverted internal limiting membrane (ILM) flap for the treatment of large macular hole.Methods:
Pseudophakic patients with idiopathic macular holes with a minimum diameter (MD) of 600-1500 µm were randomized into two groups (30 patients each) 25-gauge PPV with either inverted ILM flap (group A) or PRP (group B).Results:
Mean MD in groups A and B were 803.33 ± 120.65 µm and 784.73 ± 120.10 µm, respectively (P = 0.552). Mean base diameter in groups A and B was 1395.17 ± 240.57 µm and 1486.90 ± 281.61 µm, respectively (P = 0.180). The median presenting best-corrected visual acuity (BCVA) was logMAR 0.78 (range 0.78-1.00) and logMAR 0.78 (Range 0.60-1.00) in groups A and B, respectively (P = 0.103). Anatomical closure was achieved in 90% (n = 27/30) and 93.3% (n = 28/30) eyes in groups A and B, respectively (P = 0.158). Type 1 closure was achieved in 76.7% (n = 23/30) and 83.3% (n = 25/30) eyes in groups A and B, respectively. Median BCVA at postoperative 3-month in groups A and B was logMAR 0.60 (range 0.48-0.60) and logMAR 0.60 (range 0.48-0.78), respectively (P = 0.312). The average visual improvement was 2.0 and 2.5 early treatment diabetic retinopathy study (ETDRS) lines in groups A and B, respectively (P = 0.339). None of the patients developed postoperative exaggerated inflammatory reactions.Conclusion:
Using platelets for the treatment of large macular holes is as safe and effective as an inverted ILM flap.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Perforaciones de la Retina
/
Plasma Rico en Plaquetas
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Límite:
Humans
Idioma:
En
Revista:
Indian J Ophthalmol
Año:
2020
Tipo del documento:
Article
País de afiliación:
India