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Large nested melanoma: a clinicopathological, morphometric and cytogenetic study of 12 cases.
Leecy, Tamazin N; McQuillan, Peter; Harvey, Nathan T; Mesbah Ardakani, Nima; Van Vliet, Chris; Peverall, Joanne; Kennedy, Dagmara; Sivamoorthy, Soruba; Fruvall, Alyssa; Rijhumal, Hashika; Uzaraga, Joan; Singh, Shalinder; Wood, Benjamin A.
Afiliación
  • Leecy TN; Department of Anatomical Pathology, PathWest Laboratory Medicine, Perth, WA, Australia.
  • McQuillan P; Melbourne Pathology, Melbourne, Vic, Australia.
  • Harvey NT; Department of Anatomical Pathology, PathWest Laboratory Medicine, Perth, WA, Australia; Division of Pathology and Laboratory Medicine, Medical School, University of Western Australia, Perth, WA, Australia.
  • Mesbah Ardakani N; Department of Anatomical Pathology, PathWest Laboratory Medicine, Perth, WA, Australia; Division of Pathology and Laboratory Medicine, Medical School, University of Western Australia, Perth, WA, Australia; Murdoch University, Perth, WA, Australia.
  • Van Vliet C; Department of Anatomical Pathology, PathWest Laboratory Medicine, Perth, WA, Australia.
  • Peverall J; Department of Diagnostic Genomics, PathWest Laboratory Medicine, Perth, WA, Australia.
  • Kennedy D; Department of Diagnostic Genomics, PathWest Laboratory Medicine, Perth, WA, Australia.
  • Sivamoorthy S; Department of Diagnostic Genomics, PathWest Laboratory Medicine, Perth, WA, Australia.
  • Fruvall A; Department of Diagnostic Genomics, PathWest Laboratory Medicine, Perth, WA, Australia.
  • Rijhumal H; Department of Diagnostic Genomics, PathWest Laboratory Medicine, Perth, WA, Australia.
  • Uzaraga J; Department of Diagnostic Genomics, PathWest Laboratory Medicine, Perth, WA, Australia.
  • Singh S; Department of Anatomical Pathology, PathWest Laboratory Medicine, Perth, WA, Australia.
  • Wood BA; Department of Anatomical Pathology, PathWest Laboratory Medicine, Perth, WA, Australia; Division of Pathology and Laboratory Medicine, Medical School, University of Western Australia, Perth, WA, Australia. Electronic address: benjamin.wood@health.wa.gov.au.
Pathology ; 52(4): 431-438, 2020 Jun.
Article en En | MEDLINE | ID: mdl-32327215
A group of melanomas characterised by predominant growth as large nests within the epidermis has been described. These cases present a diagnostic challenge, as many traditional architectural criteria for the recognition of melanoma are absent. We report the clinical, histological, immunohistochemical, morphometric and cytogenetic features of a series of 12 cases of large nested melanoma. In this series, large nested melanoma accounted for 0.2% of cases of melanoma. The majority occurred on the trunk of middle aged patients with absent or minimal solar elastosis and 42% were associated with a component of benign intradermal melanocytic naevus, speaking to classification of these melanomas as falling within the spectrum of lesions developing in skin with low cumulative sun damage. In 67% of cases invasive melanoma was present. Criteria such as asymmetry, variation in nest size and intraepidermal nests with an underlying rim of junctional keratinocytes appear to be highly specific, and are strongly predictive of typical cytogenetic abnormalities of melanoma, which were identified in 92% of cases. Conversely, in addition to features which are definitionally absent or limited, features such as solar elastosis and cytological atypia do not appear to be particularly helpful in recognition of this variant.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Aberraciones Cromosómicas / Melanoma Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Pathology Año: 2020 Tipo del documento: Article País de afiliación: Australia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Aberraciones Cromosómicas / Melanoma Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Pathology Año: 2020 Tipo del documento: Article País de afiliación: Australia