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Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration.
Petit, Constance S; Lee, Jane J; Boland, Sebastian; Swarup, Sharan; Christiano, Romain; Lai, Zon Weng; Mejhert, Niklas; Elliott, Shane D; McFall, David; Haque, Sara; Huang, Eric J; Bronson, Roderick T; Harper, J Wade; Farese, Robert V; Walther, Tobias C.
Afiliación
  • Petit CS; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115.
  • Lee JJ; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
  • Boland S; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115.
  • Swarup S; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
  • Christiano R; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115.
  • Lai ZW; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
  • Mejhert N; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
  • Elliott SD; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115.
  • McFall D; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
  • Haque S; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115.
  • Huang EJ; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
  • Bronson RT; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115.
  • Harper JW; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
  • Farese RV; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115.
  • Walther TC; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
Proc Natl Acad Sci U S A ; 117(19): 10565-10574, 2020 05 12.
Article en En | MEDLINE | ID: mdl-32345721
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Esfingolípidos / Proteínas de la Membrana Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Esfingolípidos / Proteínas de la Membrana Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article