Dermatologic toxicities to immune checkpoint inhibitor therapy: A review of histopathologic features.
J Am Acad Dermatol
; 83(4): 1130-1143, 2020 Oct.
Article
en En
| MEDLINE
| ID: mdl-32360716
ABSTRACT
Antineoplastic agents that use the immune system have revolutionized cancer treatment. Specifically, implementation of immune checkpoint inhibitors, monoclonal antibodies that block cytotoxic T-lymphocyte-associated antigen-4, programmed cell death protein 1, or programmed cell death ligand 1 show improved and sustained responses in patients with cancer. However, these agents are associated with a plethora of adverse events, many manifesting in the skin. As the clinical application of cancer immunotherapies expands, understanding the clinical and histopathologic features of associated cutaneous toxicities becomes increasingly important to dermatologists, oncologists, and pathologists to ensure timely diagnosis and appropriate care. This review discusses cutaneous reactions to immune checkpoint inhibitors, focusing on histopathologic features.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Erupciones por Medicamentos
/
Inhibidores de Puntos de Control Inmunológico
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
J Am Acad Dermatol
Año:
2020
Tipo del documento:
Article