Evaluation of 5H-Thiazolo[3,2-&#945;]pyrimidin-5-ones as Potential GluN2A PET Tracers.

He, Yingfang; Whitehead, David M; Briard, Emmanuelle; Numao, Shin; Mu, Linjing; Schibli, Roger; Ametamey, Simon M; Auberson, Yves P

Evaluation of 5H-Thiazolo[3,2-α]pyrimidin-5-ones as Potential GluN2A PET Tracers.

He, Yingfang; Whitehead, David M; Briard, Emmanuelle; Numao, Shin; Mu, Linjing; Schibli, Roger; Ametamey, Simon M; Auberson, Yves P.

Afiliación

He Y; Department of Chemistry and Applied Biosciences ETH Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
Whitehead DM; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Fabrikstrasse 2, 4056, Basel, Switzerland.
Briard E; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Fabrikstrasse 2, 4056, Basel, Switzerland.
Numao S; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research, Fabrikstrasse 2, 4056, Basel, Switzerland.
Mu L; Department of Chemistry and Applied Biosciences ETH Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
Schibli R; Department of Chemistry and Applied Biosciences ETH Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
Ametamey SM; Department of Chemistry and Applied Biosciences ETH Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
Auberson YP; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Fabrikstrasse 2, 4056, Basel, Switzerland.

ChemMedChem ; 15(24): 2448-2461, 2020 12 15.

Article en En | MEDLINE | ID: mdl-32544308

Asunto(s)

Pirimidinonas/química; Radiofármacos/química; Receptores de N-Metil-D-Aspartato/metabolismo; Tiazoles/química; Animales; Encéfalo/diagnóstico por imagen; Perros; Radioisótopos de Flúor/química; Células de Riñón Canino Madin Darby; Masculino; Ratones; Microsomas Hepáticos/metabolismo; Tomografía de Emisión de Positrones; Pirimidinonas/síntesis química; Pirimidinonas/metabolismo; Radiofármacos/síntesis química; Radiofármacos/metabolismo; Ratas Wistar; Tiazoles/síntesis química; Tiazoles/metabolismo; Tritio/química

Palabras clave

NMDA; defluorination; imaging agent; radiochemistry; receptor

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinonas / Tiazoles / Receptores de N-Metil-D-Aspartato / Radiofármacos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Suiza

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