Bioinspired Non-Heme Iron Complexes: The Evolution of Facial N, N, O Ligand Design.
Chimia (Aarau)
; 74(6): 450-466, 2020 Jun 24.
Article
en En
| MEDLINE
| ID: mdl-32560750
ABSTRACT
Iron-containing metalloenzymes that contain the 2-His-1-Carboxylate facial triad at their active site are well known for their ability to activate molecular oxygen and catalyse a broad range of oxidative transformations. Many of these reactions are synthetically challenging, and developing small molecular iron-based catalysts that can achieve similar reactivity and selectivity remains a long-standing goal in homogeneous catalysis. This review focuses on the development of bioinspired facial N,N,O ligands that model the 2-His-1-Carboxylate facial triad to a greater degree of structural accuracy than many of the polydentate N-donor ligands commonly used in this field. By developing robust, well-defined N,N,O facial ligands, an increased understanding could be gained of the factors governing enzymatic reactivity and selectivity.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Chimia (Aarau)
Año:
2020
Tipo del documento:
Article
País de afiliación:
Países Bajos